Cargando…

Association of Depression and Cervical Spondylosis: A Nationwide Retrospective Propensity Score-Matched Cohort Study

Objective: Depression is a psychiatric disorder associated with poorer health outcomes. Inappropriate mechanical stress and aging are factors associated with developing cervical spondylosis. The connection between cervical spondylosis and depression is not developed. Methods: From the health insuran...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Shih-Yi, Sung, Fung-Chang, Lin, Cheng-Li, Chou, Li-Wei, Hsu, Chung-Y., Kao, Chia-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262285/
https://www.ncbi.nlm.nih.gov/pubmed/30366474
http://dx.doi.org/10.3390/jcm7110387
_version_ 1783375070266130432
author Lin, Shih-Yi
Sung, Fung-Chang
Lin, Cheng-Li
Chou, Li-Wei
Hsu, Chung-Y.
Kao, Chia-Hung
author_facet Lin, Shih-Yi
Sung, Fung-Chang
Lin, Cheng-Li
Chou, Li-Wei
Hsu, Chung-Y.
Kao, Chia-Hung
author_sort Lin, Shih-Yi
collection PubMed
description Objective: Depression is a psychiatric disorder associated with poorer health outcomes. Inappropriate mechanical stress and aging are factors associated with developing cervical spondylosis. The connection between cervical spondylosis and depression is not developed. Methods: From the health insurance claims data of Taiwan, we identified 34,166 persons newly diagnosed with depression in 2000–2010 and 34,166 persons without the disorder frequency matched by sex, age and diagnosis year. Both cohorts were followed up to the end of 2013 to estimate incident cervical spondylosis. We further examined the risk of cervical spondylosis in depressed people taking antidepressants. Results: The incidence of cervical spondylosis was 1.8-fold greater in the depression cohort than in comparison cohort (9.46 vs. 5.36 per 1000 person-years), with an adjusted hazard ratio (aHR) of 1.79 (95% confidence interval (CI) = 1.66–1.92). The incidence of cervical spondylosis increased in patients who had taken medications of serotonin-specific reuptake inhibitors (SSRIs) or of non-SSRIs than in those without these medicines (9.13 or 11.5 vs. 6.54 per 1000 person-years, respectively). Conclusions: Patients with depression are at an increased risk of developing cervical spondylosis. Additional efforts in reducing the risk of cervical spondylosis might be required in depressed individuals undergoing anti-depressive therapy.
format Online
Article
Text
id pubmed-6262285
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62622852018-12-03 Association of Depression and Cervical Spondylosis: A Nationwide Retrospective Propensity Score-Matched Cohort Study Lin, Shih-Yi Sung, Fung-Chang Lin, Cheng-Li Chou, Li-Wei Hsu, Chung-Y. Kao, Chia-Hung J Clin Med Article Objective: Depression is a psychiatric disorder associated with poorer health outcomes. Inappropriate mechanical stress and aging are factors associated with developing cervical spondylosis. The connection between cervical spondylosis and depression is not developed. Methods: From the health insurance claims data of Taiwan, we identified 34,166 persons newly diagnosed with depression in 2000–2010 and 34,166 persons without the disorder frequency matched by sex, age and diagnosis year. Both cohorts were followed up to the end of 2013 to estimate incident cervical spondylosis. We further examined the risk of cervical spondylosis in depressed people taking antidepressants. Results: The incidence of cervical spondylosis was 1.8-fold greater in the depression cohort than in comparison cohort (9.46 vs. 5.36 per 1000 person-years), with an adjusted hazard ratio (aHR) of 1.79 (95% confidence interval (CI) = 1.66–1.92). The incidence of cervical spondylosis increased in patients who had taken medications of serotonin-specific reuptake inhibitors (SSRIs) or of non-SSRIs than in those without these medicines (9.13 or 11.5 vs. 6.54 per 1000 person-years, respectively). Conclusions: Patients with depression are at an increased risk of developing cervical spondylosis. Additional efforts in reducing the risk of cervical spondylosis might be required in depressed individuals undergoing anti-depressive therapy. MDPI 2018-10-25 /pmc/articles/PMC6262285/ /pubmed/30366474 http://dx.doi.org/10.3390/jcm7110387 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Shih-Yi
Sung, Fung-Chang
Lin, Cheng-Li
Chou, Li-Wei
Hsu, Chung-Y.
Kao, Chia-Hung
Association of Depression and Cervical Spondylosis: A Nationwide Retrospective Propensity Score-Matched Cohort Study
title Association of Depression and Cervical Spondylosis: A Nationwide Retrospective Propensity Score-Matched Cohort Study
title_full Association of Depression and Cervical Spondylosis: A Nationwide Retrospective Propensity Score-Matched Cohort Study
title_fullStr Association of Depression and Cervical Spondylosis: A Nationwide Retrospective Propensity Score-Matched Cohort Study
title_full_unstemmed Association of Depression and Cervical Spondylosis: A Nationwide Retrospective Propensity Score-Matched Cohort Study
title_short Association of Depression and Cervical Spondylosis: A Nationwide Retrospective Propensity Score-Matched Cohort Study
title_sort association of depression and cervical spondylosis: a nationwide retrospective propensity score-matched cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262285/
https://www.ncbi.nlm.nih.gov/pubmed/30366474
http://dx.doi.org/10.3390/jcm7110387
work_keys_str_mv AT linshihyi associationofdepressionandcervicalspondylosisanationwideretrospectivepropensityscorematchedcohortstudy
AT sungfungchang associationofdepressionandcervicalspondylosisanationwideretrospectivepropensityscorematchedcohortstudy
AT linchengli associationofdepressionandcervicalspondylosisanationwideretrospectivepropensityscorematchedcohortstudy
AT chouliwei associationofdepressionandcervicalspondylosisanationwideretrospectivepropensityscorematchedcohortstudy
AT hsuchungy associationofdepressionandcervicalspondylosisanationwideretrospectivepropensityscorematchedcohortstudy
AT kaochiahung associationofdepressionandcervicalspondylosisanationwideretrospectivepropensityscorematchedcohortstudy