Cargando…

High Risk of Deep Neck Infection in Patients with Type 1 Diabetes Mellitus: A Nationwide Population-Based Cohort Study

Objective: To investigate the risk of deep neck infection (DNI) in patients with type 1 diabetes mellitus (T1DM). Methods: The database of the Registry for Catastrophic Illness Patients, affiliated to the Taiwan National Health Insurance Research Database, was used to conduct a retrospective cohort...

Descripción completa

Detalles Bibliográficos
Autores principales: Chang, Geng-He, Ding, Meng-Chang, Yang, Yao-Hsu, Lin, Yung-Hsiang, Liu, Chia-Yen, Lin, Meng-Hung, Wu, Ching-Yuan, Hsu, Cheng-Ming, Tsai, Ming-Shao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262288/
https://www.ncbi.nlm.nih.gov/pubmed/30366374
http://dx.doi.org/10.3390/jcm7110385
_version_ 1783375070960287744
author Chang, Geng-He
Ding, Meng-Chang
Yang, Yao-Hsu
Lin, Yung-Hsiang
Liu, Chia-Yen
Lin, Meng-Hung
Wu, Ching-Yuan
Hsu, Cheng-Ming
Tsai, Ming-Shao
author_facet Chang, Geng-He
Ding, Meng-Chang
Yang, Yao-Hsu
Lin, Yung-Hsiang
Liu, Chia-Yen
Lin, Meng-Hung
Wu, Ching-Yuan
Hsu, Cheng-Ming
Tsai, Ming-Shao
author_sort Chang, Geng-He
collection PubMed
description Objective: To investigate the risk of deep neck infection (DNI) in patients with type 1 diabetes mellitus (T1DM). Methods: The database of the Registry for Catastrophic Illness Patients, affiliated to the Taiwan National Health Insurance Research Database, was used to conduct a retrospective cohort study. In total, 5741 patients with T1DM and 22,964 matched patients without diabetes mellitus (DM) were enrolled between 2000 and 2010. The patients were followed up until death or the end of the study period (31 December 2013). The primary outcome was the occurrence of DNI. Results: Patients with T1DM exhibited a significantly higher cumulative incidence of DNI than did those without DM (p < 0.001). The Cox proportional hazards model showed that T1DM was significantly associated with a higher incidence of DNI (adjusted hazard ratio, 10.71; 95% confidence interval, 6.02–19.05; p < 0.001). The sensitivity test and subgroup analysis revealed a stable effect of T1DM on DNI risk. The therapeutic methods (surgical or nonsurgical) did not differ significantly between the T1DM and non-DM cohorts. Patients with T1DM required significantly longer hospitalization for DNI than did those without DM (9.0 ± 6.2 vs. 4.1 ± 2.0 days, p < 0.001). Furthermore, the patients with T1DM were predisposed to DNI at a younger age than were those without DM. Conclusions: T1DM is an independent risk factor for DNI and is associated with a 10-fold increase in DNI risk. The patients with T1DM require longer hospitalizations for DNI and are younger than those without DM.
format Online
Article
Text
id pubmed-6262288
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62622882018-12-03 High Risk of Deep Neck Infection in Patients with Type 1 Diabetes Mellitus: A Nationwide Population-Based Cohort Study Chang, Geng-He Ding, Meng-Chang Yang, Yao-Hsu Lin, Yung-Hsiang Liu, Chia-Yen Lin, Meng-Hung Wu, Ching-Yuan Hsu, Cheng-Ming Tsai, Ming-Shao J Clin Med Article Objective: To investigate the risk of deep neck infection (DNI) in patients with type 1 diabetes mellitus (T1DM). Methods: The database of the Registry for Catastrophic Illness Patients, affiliated to the Taiwan National Health Insurance Research Database, was used to conduct a retrospective cohort study. In total, 5741 patients with T1DM and 22,964 matched patients without diabetes mellitus (DM) were enrolled between 2000 and 2010. The patients were followed up until death or the end of the study period (31 December 2013). The primary outcome was the occurrence of DNI. Results: Patients with T1DM exhibited a significantly higher cumulative incidence of DNI than did those without DM (p < 0.001). The Cox proportional hazards model showed that T1DM was significantly associated with a higher incidence of DNI (adjusted hazard ratio, 10.71; 95% confidence interval, 6.02–19.05; p < 0.001). The sensitivity test and subgroup analysis revealed a stable effect of T1DM on DNI risk. The therapeutic methods (surgical or nonsurgical) did not differ significantly between the T1DM and non-DM cohorts. Patients with T1DM required significantly longer hospitalization for DNI than did those without DM (9.0 ± 6.2 vs. 4.1 ± 2.0 days, p < 0.001). Furthermore, the patients with T1DM were predisposed to DNI at a younger age than were those without DM. Conclusions: T1DM is an independent risk factor for DNI and is associated with a 10-fold increase in DNI risk. The patients with T1DM require longer hospitalizations for DNI and are younger than those without DM. MDPI 2018-10-25 /pmc/articles/PMC6262288/ /pubmed/30366374 http://dx.doi.org/10.3390/jcm7110385 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Geng-He
Ding, Meng-Chang
Yang, Yao-Hsu
Lin, Yung-Hsiang
Liu, Chia-Yen
Lin, Meng-Hung
Wu, Ching-Yuan
Hsu, Cheng-Ming
Tsai, Ming-Shao
High Risk of Deep Neck Infection in Patients with Type 1 Diabetes Mellitus: A Nationwide Population-Based Cohort Study
title High Risk of Deep Neck Infection in Patients with Type 1 Diabetes Mellitus: A Nationwide Population-Based Cohort Study
title_full High Risk of Deep Neck Infection in Patients with Type 1 Diabetes Mellitus: A Nationwide Population-Based Cohort Study
title_fullStr High Risk of Deep Neck Infection in Patients with Type 1 Diabetes Mellitus: A Nationwide Population-Based Cohort Study
title_full_unstemmed High Risk of Deep Neck Infection in Patients with Type 1 Diabetes Mellitus: A Nationwide Population-Based Cohort Study
title_short High Risk of Deep Neck Infection in Patients with Type 1 Diabetes Mellitus: A Nationwide Population-Based Cohort Study
title_sort high risk of deep neck infection in patients with type 1 diabetes mellitus: a nationwide population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262288/
https://www.ncbi.nlm.nih.gov/pubmed/30366374
http://dx.doi.org/10.3390/jcm7110385
work_keys_str_mv AT changgenghe highriskofdeepneckinfectioninpatientswithtype1diabetesmellitusanationwidepopulationbasedcohortstudy
AT dingmengchang highriskofdeepneckinfectioninpatientswithtype1diabetesmellitusanationwidepopulationbasedcohortstudy
AT yangyaohsu highriskofdeepneckinfectioninpatientswithtype1diabetesmellitusanationwidepopulationbasedcohortstudy
AT linyunghsiang highriskofdeepneckinfectioninpatientswithtype1diabetesmellitusanationwidepopulationbasedcohortstudy
AT liuchiayen highriskofdeepneckinfectioninpatientswithtype1diabetesmellitusanationwidepopulationbasedcohortstudy
AT linmenghung highriskofdeepneckinfectioninpatientswithtype1diabetesmellitusanationwidepopulationbasedcohortstudy
AT wuchingyuan highriskofdeepneckinfectioninpatientswithtype1diabetesmellitusanationwidepopulationbasedcohortstudy
AT hsuchengming highriskofdeepneckinfectioninpatientswithtype1diabetesmellitusanationwidepopulationbasedcohortstudy
AT tsaimingshao highriskofdeepneckinfectioninpatientswithtype1diabetesmellitusanationwidepopulationbasedcohortstudy