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The Role of Irisin in Alzheimer’s Disease
Alzheimer’s disease (AD) is characterized by progressive memory dysfunction, oxidative stress, and presence of senile plaques formed by amyloid beta (Aβ) accumulation in the brain. AD is one of the most important causes of morbidity and mortality worldwide. AD has a variety of risk factors, includin...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262319/ https://www.ncbi.nlm.nih.gov/pubmed/30388754 http://dx.doi.org/10.3390/jcm7110407 |
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author | Kim, Oh Yoen Song, Juhyun |
author_facet | Kim, Oh Yoen Song, Juhyun |
author_sort | Kim, Oh Yoen |
collection | PubMed |
description | Alzheimer’s disease (AD) is characterized by progressive memory dysfunction, oxidative stress, and presence of senile plaques formed by amyloid beta (Aβ) accumulation in the brain. AD is one of the most important causes of morbidity and mortality worldwide. AD has a variety of risk factors, including environmental factors, metabolic dysfunction, and genetic background. Recent research has highlighted the relationship between AD and systemic metabolic changes such as glucose and lipid imbalance and insulin resistance. Irisin, a myokine closely linked to exercise, has been associated with glucose metabolism, insulin sensitivity, and fat browning. Recent studies have suggested that irisin is involved in the process in central nervous system (CNS) such as neurogenesis and has reported the effects of irisin on AD as one of the neurodegenerative disease. Here, we review the roles of irisin with respect to AD and suggest that irisin highlight therapeutic important roles in AD. Thus, we propose that irisin could be a potential future target for ameliorating AD pathology and preventing AD onset. |
format | Online Article Text |
id | pubmed-6262319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62623192018-12-03 The Role of Irisin in Alzheimer’s Disease Kim, Oh Yoen Song, Juhyun J Clin Med Review Alzheimer’s disease (AD) is characterized by progressive memory dysfunction, oxidative stress, and presence of senile plaques formed by amyloid beta (Aβ) accumulation in the brain. AD is one of the most important causes of morbidity and mortality worldwide. AD has a variety of risk factors, including environmental factors, metabolic dysfunction, and genetic background. Recent research has highlighted the relationship between AD and systemic metabolic changes such as glucose and lipid imbalance and insulin resistance. Irisin, a myokine closely linked to exercise, has been associated with glucose metabolism, insulin sensitivity, and fat browning. Recent studies have suggested that irisin is involved in the process in central nervous system (CNS) such as neurogenesis and has reported the effects of irisin on AD as one of the neurodegenerative disease. Here, we review the roles of irisin with respect to AD and suggest that irisin highlight therapeutic important roles in AD. Thus, we propose that irisin could be a potential future target for ameliorating AD pathology and preventing AD onset. MDPI 2018-11-01 /pmc/articles/PMC6262319/ /pubmed/30388754 http://dx.doi.org/10.3390/jcm7110407 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kim, Oh Yoen Song, Juhyun The Role of Irisin in Alzheimer’s Disease |
title | The Role of Irisin in Alzheimer’s Disease |
title_full | The Role of Irisin in Alzheimer’s Disease |
title_fullStr | The Role of Irisin in Alzheimer’s Disease |
title_full_unstemmed | The Role of Irisin in Alzheimer’s Disease |
title_short | The Role of Irisin in Alzheimer’s Disease |
title_sort | role of irisin in alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262319/ https://www.ncbi.nlm.nih.gov/pubmed/30388754 http://dx.doi.org/10.3390/jcm7110407 |
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