Cargando…
Prediction of Acute Kidney Injury after Liver Transplantation: Machine Learning Approaches vs. Logistic Regression Model
Acute kidney injury (AKI) after liver transplantation has been reported to be associated with increased mortality. Recently, machine learning approaches were reported to have better predictive ability than the classic statistical analysis. We compared the performance of machine learning approaches w...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262324/ https://www.ncbi.nlm.nih.gov/pubmed/30413107 http://dx.doi.org/10.3390/jcm7110428 |
_version_ | 1783375079423344640 |
---|---|
author | Lee, Hyung-Chul Yoon, Soo Bin Yang, Seong-Mi Kim, Won Ho Ryu, Ho-Geol Jung, Chul-Woo Suh, Kyung-Suk Lee, Kook Hyun |
author_facet | Lee, Hyung-Chul Yoon, Soo Bin Yang, Seong-Mi Kim, Won Ho Ryu, Ho-Geol Jung, Chul-Woo Suh, Kyung-Suk Lee, Kook Hyun |
author_sort | Lee, Hyung-Chul |
collection | PubMed |
description | Acute kidney injury (AKI) after liver transplantation has been reported to be associated with increased mortality. Recently, machine learning approaches were reported to have better predictive ability than the classic statistical analysis. We compared the performance of machine learning approaches with that of logistic regression analysis to predict AKI after liver transplantation. We reviewed 1211 patients and preoperative and intraoperative anesthesia and surgery-related variables were obtained. The primary outcome was postoperative AKI defined by acute kidney injury network criteria. The following machine learning techniques were used: decision tree, random forest, gradient boosting machine, support vector machine, naïve Bayes, multilayer perceptron, and deep belief networks. These techniques were compared with logistic regression analysis regarding the area under the receiver-operating characteristic curve (AUROC). AKI developed in 365 patients (30.1%). The performance in terms of AUROC was best in gradient boosting machine among all analyses to predict AKI of all stages (0.90, 95% confidence interval [CI] 0.86–0.93) or stage 2 or 3 AKI. The AUROC of logistic regression analysis was 0.61 (95% CI 0.56–0.66). Decision tree and random forest techniques showed moderate performance (AUROC 0.86 and 0.85, respectively). The AUROC of support the vector machine, naïve Bayes, neural network, and deep belief network was smaller than that of the other models. In our comparison of seven machine learning approaches with logistic regression analysis, the gradient boosting machine showed the best performance with the highest AUROC. An internet-based risk estimator was developed based on our model of gradient boosting. However, prospective studies are required to validate our results. |
format | Online Article Text |
id | pubmed-6262324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62623242018-12-03 Prediction of Acute Kidney Injury after Liver Transplantation: Machine Learning Approaches vs. Logistic Regression Model Lee, Hyung-Chul Yoon, Soo Bin Yang, Seong-Mi Kim, Won Ho Ryu, Ho-Geol Jung, Chul-Woo Suh, Kyung-Suk Lee, Kook Hyun J Clin Med Article Acute kidney injury (AKI) after liver transplantation has been reported to be associated with increased mortality. Recently, machine learning approaches were reported to have better predictive ability than the classic statistical analysis. We compared the performance of machine learning approaches with that of logistic regression analysis to predict AKI after liver transplantation. We reviewed 1211 patients and preoperative and intraoperative anesthesia and surgery-related variables were obtained. The primary outcome was postoperative AKI defined by acute kidney injury network criteria. The following machine learning techniques were used: decision tree, random forest, gradient boosting machine, support vector machine, naïve Bayes, multilayer perceptron, and deep belief networks. These techniques were compared with logistic regression analysis regarding the area under the receiver-operating characteristic curve (AUROC). AKI developed in 365 patients (30.1%). The performance in terms of AUROC was best in gradient boosting machine among all analyses to predict AKI of all stages (0.90, 95% confidence interval [CI] 0.86–0.93) or stage 2 or 3 AKI. The AUROC of logistic regression analysis was 0.61 (95% CI 0.56–0.66). Decision tree and random forest techniques showed moderate performance (AUROC 0.86 and 0.85, respectively). The AUROC of support the vector machine, naïve Bayes, neural network, and deep belief network was smaller than that of the other models. In our comparison of seven machine learning approaches with logistic regression analysis, the gradient boosting machine showed the best performance with the highest AUROC. An internet-based risk estimator was developed based on our model of gradient boosting. However, prospective studies are required to validate our results. MDPI 2018-11-08 /pmc/articles/PMC6262324/ /pubmed/30413107 http://dx.doi.org/10.3390/jcm7110428 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Hyung-Chul Yoon, Soo Bin Yang, Seong-Mi Kim, Won Ho Ryu, Ho-Geol Jung, Chul-Woo Suh, Kyung-Suk Lee, Kook Hyun Prediction of Acute Kidney Injury after Liver Transplantation: Machine Learning Approaches vs. Logistic Regression Model |
title | Prediction of Acute Kidney Injury after Liver Transplantation: Machine Learning Approaches vs. Logistic Regression Model |
title_full | Prediction of Acute Kidney Injury after Liver Transplantation: Machine Learning Approaches vs. Logistic Regression Model |
title_fullStr | Prediction of Acute Kidney Injury after Liver Transplantation: Machine Learning Approaches vs. Logistic Regression Model |
title_full_unstemmed | Prediction of Acute Kidney Injury after Liver Transplantation: Machine Learning Approaches vs. Logistic Regression Model |
title_short | Prediction of Acute Kidney Injury after Liver Transplantation: Machine Learning Approaches vs. Logistic Regression Model |
title_sort | prediction of acute kidney injury after liver transplantation: machine learning approaches vs. logistic regression model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262324/ https://www.ncbi.nlm.nih.gov/pubmed/30413107 http://dx.doi.org/10.3390/jcm7110428 |
work_keys_str_mv | AT leehyungchul predictionofacutekidneyinjuryafterlivertransplantationmachinelearningapproachesvslogisticregressionmodel AT yoonsoobin predictionofacutekidneyinjuryafterlivertransplantationmachinelearningapproachesvslogisticregressionmodel AT yangseongmi predictionofacutekidneyinjuryafterlivertransplantationmachinelearningapproachesvslogisticregressionmodel AT kimwonho predictionofacutekidneyinjuryafterlivertransplantationmachinelearningapproachesvslogisticregressionmodel AT ryuhogeol predictionofacutekidneyinjuryafterlivertransplantationmachinelearningapproachesvslogisticregressionmodel AT jungchulwoo predictionofacutekidneyinjuryafterlivertransplantationmachinelearningapproachesvslogisticregressionmodel AT suhkyungsuk predictionofacutekidneyinjuryafterlivertransplantationmachinelearningapproachesvslogisticregressionmodel AT leekookhyun predictionofacutekidneyinjuryafterlivertransplantationmachinelearningapproachesvslogisticregressionmodel |