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Increased Level of Angiopoietin Like Proteins 4 and 8 in People With Sleep Apnea

Objective: Obstructive sleep apnea (OSA) is a sleep disorder caused by the complete or partial obstruction of the upper airways. The worldwide prevalence of OSA is increasing due to its close association with obesity epidemic and multiple health complications, such as hypertension, cardiovascular di...

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Autores principales: Al-Terki, Abdulmohsen, Abu-Farha, Mohamed, AlKhairi, Irina, Cherian, Preethi T., Sriraman, Devarajan, Shyamsundar, Ambika, Ali, Shamsha, Almulla, Fahd, Tuomilehto, Jaakko, Abubaker, Jehad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262344/
https://www.ncbi.nlm.nih.gov/pubmed/30524367
http://dx.doi.org/10.3389/fendo.2018.00651
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author Al-Terki, Abdulmohsen
Abu-Farha, Mohamed
AlKhairi, Irina
Cherian, Preethi T.
Sriraman, Devarajan
Shyamsundar, Ambika
Ali, Shamsha
Almulla, Fahd
Tuomilehto, Jaakko
Abubaker, Jehad A.
author_facet Al-Terki, Abdulmohsen
Abu-Farha, Mohamed
AlKhairi, Irina
Cherian, Preethi T.
Sriraman, Devarajan
Shyamsundar, Ambika
Ali, Shamsha
Almulla, Fahd
Tuomilehto, Jaakko
Abubaker, Jehad A.
author_sort Al-Terki, Abdulmohsen
collection PubMed
description Objective: Obstructive sleep apnea (OSA) is a sleep disorder caused by the complete or partial obstruction of the upper airways. The worldwide prevalence of OSA is increasing due to its close association with obesity epidemic and multiple health complications, such as hypertension, cardiovascular disease, and Type 2 diabetes. Angiopoietin-like protein (ANGPTL)-4 and ANGPTL8 (betatrophin) have been suggested to play a role in the development of these diseases through their role in regulating the metabolism of plasma lipid molecules. This study was designed to evaluate ANGPTL4 and 8 levels in an OSA group and a control group to clarify the effect of OSA on ANGPTL4 and 8 levels. Methods: In total, 74 subjects were enrolled in this study, including 22 age- and body mass index (BMI)-matched controls with the Apnea Hypopnea Index (AHI) score of <5 events/h and 52 subjects with an AHI score of >5 events/h. Sleep apnea was assessed using a portable sleep test. ANGPTL4 and 8 levels were measured in plasma samples using enzyme-linked immunosorbent assay. Results: Mean AHI score (2.5 ± 1.6) in the control group was significantly lower than that in the OSA group (22.9 ± 17.9; p < 0.0001). Leptin, interleukin-(IL) 6, insulin, and HOMA-IR values were higher in the OSA group than in the control group. ANGPTL8 level was higher in the OSA group (1130.0 ± 108.61 pg/mL) than in the control group (809.39 ± 108.78 pg/mL; p = 0.041). Similarly, ANGPTL4 was higher in the OSA group (179.26 ± 12.89 ng/mL) than in the control group (142.63 ±7.99 ng/mL; p = 0.018). Conclusion: Our findings demonstrate that ANGPTL4 and 8 levels were increased in subjects with OSA, suggesting that the upregulation of these lipid metabolism regulators might play a role in lipid dysregulation observed in people with OSA.
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spelling pubmed-62623442018-12-06 Increased Level of Angiopoietin Like Proteins 4 and 8 in People With Sleep Apnea Al-Terki, Abdulmohsen Abu-Farha, Mohamed AlKhairi, Irina Cherian, Preethi T. Sriraman, Devarajan Shyamsundar, Ambika Ali, Shamsha Almulla, Fahd Tuomilehto, Jaakko Abubaker, Jehad A. Front Endocrinol (Lausanne) Endocrinology Objective: Obstructive sleep apnea (OSA) is a sleep disorder caused by the complete or partial obstruction of the upper airways. The worldwide prevalence of OSA is increasing due to its close association with obesity epidemic and multiple health complications, such as hypertension, cardiovascular disease, and Type 2 diabetes. Angiopoietin-like protein (ANGPTL)-4 and ANGPTL8 (betatrophin) have been suggested to play a role in the development of these diseases through their role in regulating the metabolism of plasma lipid molecules. This study was designed to evaluate ANGPTL4 and 8 levels in an OSA group and a control group to clarify the effect of OSA on ANGPTL4 and 8 levels. Methods: In total, 74 subjects were enrolled in this study, including 22 age- and body mass index (BMI)-matched controls with the Apnea Hypopnea Index (AHI) score of <5 events/h and 52 subjects with an AHI score of >5 events/h. Sleep apnea was assessed using a portable sleep test. ANGPTL4 and 8 levels were measured in plasma samples using enzyme-linked immunosorbent assay. Results: Mean AHI score (2.5 ± 1.6) in the control group was significantly lower than that in the OSA group (22.9 ± 17.9; p < 0.0001). Leptin, interleukin-(IL) 6, insulin, and HOMA-IR values were higher in the OSA group than in the control group. ANGPTL8 level was higher in the OSA group (1130.0 ± 108.61 pg/mL) than in the control group (809.39 ± 108.78 pg/mL; p = 0.041). Similarly, ANGPTL4 was higher in the OSA group (179.26 ± 12.89 ng/mL) than in the control group (142.63 ±7.99 ng/mL; p = 0.018). Conclusion: Our findings demonstrate that ANGPTL4 and 8 levels were increased in subjects with OSA, suggesting that the upregulation of these lipid metabolism regulators might play a role in lipid dysregulation observed in people with OSA. Frontiers Media S.A. 2018-11-13 /pmc/articles/PMC6262344/ /pubmed/30524367 http://dx.doi.org/10.3389/fendo.2018.00651 Text en Copyright © 2018 Al-Terki, Abu-Farha, AlKhairi, Cherian, Sriraman, Shyamsundar, Ali, Almulla, Tuomilehto and Abubaker. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Al-Terki, Abdulmohsen
Abu-Farha, Mohamed
AlKhairi, Irina
Cherian, Preethi T.
Sriraman, Devarajan
Shyamsundar, Ambika
Ali, Shamsha
Almulla, Fahd
Tuomilehto, Jaakko
Abubaker, Jehad A.
Increased Level of Angiopoietin Like Proteins 4 and 8 in People With Sleep Apnea
title Increased Level of Angiopoietin Like Proteins 4 and 8 in People With Sleep Apnea
title_full Increased Level of Angiopoietin Like Proteins 4 and 8 in People With Sleep Apnea
title_fullStr Increased Level of Angiopoietin Like Proteins 4 and 8 in People With Sleep Apnea
title_full_unstemmed Increased Level of Angiopoietin Like Proteins 4 and 8 in People With Sleep Apnea
title_short Increased Level of Angiopoietin Like Proteins 4 and 8 in People With Sleep Apnea
title_sort increased level of angiopoietin like proteins 4 and 8 in people with sleep apnea
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262344/
https://www.ncbi.nlm.nih.gov/pubmed/30524367
http://dx.doi.org/10.3389/fendo.2018.00651
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