Post-Translational Modifications and Diastolic Calcium Leak Associated to the Novel RyR2-D3638A Mutation Lead to CPVT in Patient-Specific hiPSC-Derived Cardiomyocytes

Background: Sarcoplasmic reticulum Ca(2+) leak and post-translational modifications under stress have been implicated in catecholaminergic polymorphic ventricular tachycardia (CPVT), a highly lethal inherited arrhythmogenic disorder. Human induced pluripotent stem cells (hiPSCs) offer a unique oppor...

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Detalles Bibliográficos
Autores principales: Acimovic, Ivana, Refaat, Marwan M., Moreau, Adrien, Salykin, Anton, Reiken, Steve, Sleiman, Yvonne, Souidi, Monia, Přibyl, Jan, Kajava, Andrey V., Richard, Sylvain, Lu, Jonathan T., Chevalier, Philippe, Skládal, Petr, Dvořak, Petr, Rotrekl, Vladimir, Marks, Andrew R., Scheinman, Melvin M., Lacampagne, Alain, Meli, Albano C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262462/
https://www.ncbi.nlm.nih.gov/pubmed/30413023
http://dx.doi.org/10.3390/jcm7110423

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