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Circulating Levels of Osteopontin Predict Patients’ Outcome after Resection of Colorectal Liver Metastases

For colorectal liver metastases (CRLM), surgical resection is the only potentially curative therapy, but even successfully resected patients often face disease recurrence, leading to 5-year survival rate below 50%. Despite available preoperative stratification strategies, it is not fully elucidated...

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Autores principales: Loosen, Sven H., Heise, Daniel, Dejong, Cees H., Roy, Sanchari, Tacke, Frank, Trautwein, Christian, Roderburg, Christoph, Luedde, Tom, Neumann, Ulf P., Binnebösel, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262509/
https://www.ncbi.nlm.nih.gov/pubmed/30373147
http://dx.doi.org/10.3390/jcm7110390
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author Loosen, Sven H.
Heise, Daniel
Dejong, Cees H.
Roy, Sanchari
Tacke, Frank
Trautwein, Christian
Roderburg, Christoph
Luedde, Tom
Neumann, Ulf P.
Binnebösel, Marcel
author_facet Loosen, Sven H.
Heise, Daniel
Dejong, Cees H.
Roy, Sanchari
Tacke, Frank
Trautwein, Christian
Roderburg, Christoph
Luedde, Tom
Neumann, Ulf P.
Binnebösel, Marcel
author_sort Loosen, Sven H.
collection PubMed
description For colorectal liver metastases (CRLM), surgical resection is the only potentially curative therapy, but even successfully resected patients often face disease recurrence, leading to 5-year survival rate below 50%. Despite available preoperative stratification strategies, it is not fully elucidated which patients actually benefit from CRLM resection. Here we evaluated osteopontin, a secreted glyco-phosphoprotein, as a biomarker in the context of CRLM resection. Tissue levels of osteopontin were analysed in CRLM using reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry. Pre- and postoperative osteopontin serum concentrations were analysed by enzyme-linked immunosorbent assay (ELISA) in 125 patients undergoing resection of CRLM as well as 65 healthy controls. Correlating with an upregulation of osteopontin tissue expression in CRLM, osteopontin serum levels were significantly elevated in patients with CRLM compared to healthy controls. Importantly, high pre- and post-operative osteopontin serum levels were associated with a poor prognosis after tumour resection. Patients with initial osteopontin serum levels above our ideal cut-off value of 264.4 ng/mL showed a significantly impaired median overall survival of 304 days compared to 1394 days for patients with low osteopontin levels. Together, our data suggest a role of osteopontin as a prognostic biomarker in patients with resectable CRLM that might help to identify patients who particularly benefit from liver resection.
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spelling pubmed-62625092018-12-03 Circulating Levels of Osteopontin Predict Patients’ Outcome after Resection of Colorectal Liver Metastases Loosen, Sven H. Heise, Daniel Dejong, Cees H. Roy, Sanchari Tacke, Frank Trautwein, Christian Roderburg, Christoph Luedde, Tom Neumann, Ulf P. Binnebösel, Marcel J Clin Med Article For colorectal liver metastases (CRLM), surgical resection is the only potentially curative therapy, but even successfully resected patients often face disease recurrence, leading to 5-year survival rate below 50%. Despite available preoperative stratification strategies, it is not fully elucidated which patients actually benefit from CRLM resection. Here we evaluated osteopontin, a secreted glyco-phosphoprotein, as a biomarker in the context of CRLM resection. Tissue levels of osteopontin were analysed in CRLM using reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry. Pre- and postoperative osteopontin serum concentrations were analysed by enzyme-linked immunosorbent assay (ELISA) in 125 patients undergoing resection of CRLM as well as 65 healthy controls. Correlating with an upregulation of osteopontin tissue expression in CRLM, osteopontin serum levels were significantly elevated in patients with CRLM compared to healthy controls. Importantly, high pre- and post-operative osteopontin serum levels were associated with a poor prognosis after tumour resection. Patients with initial osteopontin serum levels above our ideal cut-off value of 264.4 ng/mL showed a significantly impaired median overall survival of 304 days compared to 1394 days for patients with low osteopontin levels. Together, our data suggest a role of osteopontin as a prognostic biomarker in patients with resectable CRLM that might help to identify patients who particularly benefit from liver resection. MDPI 2018-10-26 /pmc/articles/PMC6262509/ /pubmed/30373147 http://dx.doi.org/10.3390/jcm7110390 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Loosen, Sven H.
Heise, Daniel
Dejong, Cees H.
Roy, Sanchari
Tacke, Frank
Trautwein, Christian
Roderburg, Christoph
Luedde, Tom
Neumann, Ulf P.
Binnebösel, Marcel
Circulating Levels of Osteopontin Predict Patients’ Outcome after Resection of Colorectal Liver Metastases
title Circulating Levels of Osteopontin Predict Patients’ Outcome after Resection of Colorectal Liver Metastases
title_full Circulating Levels of Osteopontin Predict Patients’ Outcome after Resection of Colorectal Liver Metastases
title_fullStr Circulating Levels of Osteopontin Predict Patients’ Outcome after Resection of Colorectal Liver Metastases
title_full_unstemmed Circulating Levels of Osteopontin Predict Patients’ Outcome after Resection of Colorectal Liver Metastases
title_short Circulating Levels of Osteopontin Predict Patients’ Outcome after Resection of Colorectal Liver Metastases
title_sort circulating levels of osteopontin predict patients’ outcome after resection of colorectal liver metastases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262509/
https://www.ncbi.nlm.nih.gov/pubmed/30373147
http://dx.doi.org/10.3390/jcm7110390
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