Cargando…

Gamma Glutamyl Transferase and Uric Acid Levels Can Be Associated with the Prognosis of Patients in the Pediatric Intensive Care Unit

Introduction: Gamma glutamyl transferase (GGT) and uric acid (UA) are reported to be predictive markers in various disorders. It has been reported that these biomarkers can be used to indicate increased risk of mortality in critically ill patients. Herein, we aimed to evaluate the effects of the ini...

Descripción completa

Detalles Bibliográficos
Autores principales: Aygun, Fatih, Kirkoc, Ruhsar, Aygun, Deniz, Cam, Halit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262526/
https://www.ncbi.nlm.nih.gov/pubmed/30380730
http://dx.doi.org/10.3390/children5110147
_version_ 1783375123293667328
author Aygun, Fatih
Kirkoc, Ruhsar
Aygun, Deniz
Cam, Halit
author_facet Aygun, Fatih
Kirkoc, Ruhsar
Aygun, Deniz
Cam, Halit
author_sort Aygun, Fatih
collection PubMed
description Introduction: Gamma glutamyl transferase (GGT) and uric acid (UA) are reported to be predictive markers in various disorders. It has been reported that these biomarkers can be used to indicate increased risk of mortality in critically ill patients. Herein, we aimed to evaluate the effects of the initial serum GGT and UA levels on the outcomes of patients in the pediatric intensive care unit (PICU) and to investigate if these biomarkers can be used to predict pediatric mortality. Materials and Methods: The relationship between the initial GGT and UA levels and invasive mechanical ventilation (IMV) and noninvasive mechanical ventilation (NIV) support, inotropic drug need, acute renal kidney injury (AKI), continuous renal replacement therapy (CRRT), presence of sepsis, mortality, and hospitalization period were investigated retrospectively. Results: In all, 236 patients (117 males and 119 females) were included in the study. The age distribution of the patients was 1–12 years. There was a statistically significant relationship between GGT levels in the first biochemical analysis performed during admission and inotropic drug use, AKI, duration of hospitalization in intensive care unit, and sepsis. There was a statistically significant relationship between initial UA levels and inotropic drug use, AKI, CCRT, and sepsis. Conclusion: We suggest that initial GGT and UA levels during admission could be used to predict the outcomes of patients in PICU.
format Online
Article
Text
id pubmed-6262526
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62625262018-12-03 Gamma Glutamyl Transferase and Uric Acid Levels Can Be Associated with the Prognosis of Patients in the Pediatric Intensive Care Unit Aygun, Fatih Kirkoc, Ruhsar Aygun, Deniz Cam, Halit Children (Basel) Article Introduction: Gamma glutamyl transferase (GGT) and uric acid (UA) are reported to be predictive markers in various disorders. It has been reported that these biomarkers can be used to indicate increased risk of mortality in critically ill patients. Herein, we aimed to evaluate the effects of the initial serum GGT and UA levels on the outcomes of patients in the pediatric intensive care unit (PICU) and to investigate if these biomarkers can be used to predict pediatric mortality. Materials and Methods: The relationship between the initial GGT and UA levels and invasive mechanical ventilation (IMV) and noninvasive mechanical ventilation (NIV) support, inotropic drug need, acute renal kidney injury (AKI), continuous renal replacement therapy (CRRT), presence of sepsis, mortality, and hospitalization period were investigated retrospectively. Results: In all, 236 patients (117 males and 119 females) were included in the study. The age distribution of the patients was 1–12 years. There was a statistically significant relationship between GGT levels in the first biochemical analysis performed during admission and inotropic drug use, AKI, duration of hospitalization in intensive care unit, and sepsis. There was a statistically significant relationship between initial UA levels and inotropic drug use, AKI, CCRT, and sepsis. Conclusion: We suggest that initial GGT and UA levels during admission could be used to predict the outcomes of patients in PICU. MDPI 2018-10-30 /pmc/articles/PMC6262526/ /pubmed/30380730 http://dx.doi.org/10.3390/children5110147 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aygun, Fatih
Kirkoc, Ruhsar
Aygun, Deniz
Cam, Halit
Gamma Glutamyl Transferase and Uric Acid Levels Can Be Associated with the Prognosis of Patients in the Pediatric Intensive Care Unit
title Gamma Glutamyl Transferase and Uric Acid Levels Can Be Associated with the Prognosis of Patients in the Pediatric Intensive Care Unit
title_full Gamma Glutamyl Transferase and Uric Acid Levels Can Be Associated with the Prognosis of Patients in the Pediatric Intensive Care Unit
title_fullStr Gamma Glutamyl Transferase and Uric Acid Levels Can Be Associated with the Prognosis of Patients in the Pediatric Intensive Care Unit
title_full_unstemmed Gamma Glutamyl Transferase and Uric Acid Levels Can Be Associated with the Prognosis of Patients in the Pediatric Intensive Care Unit
title_short Gamma Glutamyl Transferase and Uric Acid Levels Can Be Associated with the Prognosis of Patients in the Pediatric Intensive Care Unit
title_sort gamma glutamyl transferase and uric acid levels can be associated with the prognosis of patients in the pediatric intensive care unit
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262526/
https://www.ncbi.nlm.nih.gov/pubmed/30380730
http://dx.doi.org/10.3390/children5110147
work_keys_str_mv AT aygunfatih gammaglutamyltransferaseanduricacidlevelscanbeassociatedwiththeprognosisofpatientsinthepediatricintensivecareunit
AT kirkocruhsar gammaglutamyltransferaseanduricacidlevelscanbeassociatedwiththeprognosisofpatientsinthepediatricintensivecareunit
AT aygundeniz gammaglutamyltransferaseanduricacidlevelscanbeassociatedwiththeprognosisofpatientsinthepediatricintensivecareunit
AT camhalit gammaglutamyltransferaseanduricacidlevelscanbeassociatedwiththeprognosisofpatientsinthepediatricintensivecareunit