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Mortality Risks among Various Primary Renal Diseases in Children and Adolescents on Chronic Dialysis
There is little information available on the association between primary renal disease (PRD) and long-term mortality in the pediatric dialysis population. The objective of this study was to explore mortality risks in children and adolescents on chronic dialysis, specifically focused on the risk of v...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262556/ https://www.ncbi.nlm.nih.gov/pubmed/30400589 http://dx.doi.org/10.3390/jcm7110414 |
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author | Chou, Hsin-Hsu Chiou, Yuan-Yow Chiou, Yee-Hsuan Tain, You-Lin Wang, Hsin-Hui Yu, Mei-Ching Hsu, Chih-Cheng Lin, Ching-Yuang |
author_facet | Chou, Hsin-Hsu Chiou, Yuan-Yow Chiou, Yee-Hsuan Tain, You-Lin Wang, Hsin-Hui Yu, Mei-Ching Hsu, Chih-Cheng Lin, Ching-Yuang |
author_sort | Chou, Hsin-Hsu |
collection | PubMed |
description | There is little information available on the association between primary renal disease (PRD) and long-term mortality in the pediatric dialysis population. The objective of this study was to explore mortality risks in children and adolescents on chronic dialysis, specifically focused on the risk of various PRDs. The study cohort included children and adolescents with end-stage renal disease (ESRD) (aged < 20 years) who had received dialysis for at least 90 days between 2000 and 2014 and were identified from Taiwan’s National Health Insurance medical claims. A total of 530 children and adolescents were included in the study. The median age of the included patients was 13.6 years and 305 (57.5%) patients were males. One hundred and seven patients died during the follow-up period and the median survival time was 6.0 years. Mortality was highest in the youngest patients. For patients with the following PRDs, mortality was significantly higher than that in patients with primary glomerulonephritis: secondary glomerulonephritis (adjusted hazard ratio (aHR): 2.50; 95% confidence interval (CI): 1.03–6.08), urologic disorder (aHR: 4.77; 95% CI: 1.69–13.46), and metabolic diseases (aHR: 5.57; 95% CI: 1.84–16.85). Several kinds of PRDs appear to have high mortality risks in the pediatric dialysis population. These differences in mortality risk highlight the importance of the focused clinical management of these high-risk subgroups. |
format | Online Article Text |
id | pubmed-6262556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62625562018-12-03 Mortality Risks among Various Primary Renal Diseases in Children and Adolescents on Chronic Dialysis Chou, Hsin-Hsu Chiou, Yuan-Yow Chiou, Yee-Hsuan Tain, You-Lin Wang, Hsin-Hui Yu, Mei-Ching Hsu, Chih-Cheng Lin, Ching-Yuang J Clin Med Article There is little information available on the association between primary renal disease (PRD) and long-term mortality in the pediatric dialysis population. The objective of this study was to explore mortality risks in children and adolescents on chronic dialysis, specifically focused on the risk of various PRDs. The study cohort included children and adolescents with end-stage renal disease (ESRD) (aged < 20 years) who had received dialysis for at least 90 days between 2000 and 2014 and were identified from Taiwan’s National Health Insurance medical claims. A total of 530 children and adolescents were included in the study. The median age of the included patients was 13.6 years and 305 (57.5%) patients were males. One hundred and seven patients died during the follow-up period and the median survival time was 6.0 years. Mortality was highest in the youngest patients. For patients with the following PRDs, mortality was significantly higher than that in patients with primary glomerulonephritis: secondary glomerulonephritis (adjusted hazard ratio (aHR): 2.50; 95% confidence interval (CI): 1.03–6.08), urologic disorder (aHR: 4.77; 95% CI: 1.69–13.46), and metabolic diseases (aHR: 5.57; 95% CI: 1.84–16.85). Several kinds of PRDs appear to have high mortality risks in the pediatric dialysis population. These differences in mortality risk highlight the importance of the focused clinical management of these high-risk subgroups. MDPI 2018-11-05 /pmc/articles/PMC6262556/ /pubmed/30400589 http://dx.doi.org/10.3390/jcm7110414 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chou, Hsin-Hsu Chiou, Yuan-Yow Chiou, Yee-Hsuan Tain, You-Lin Wang, Hsin-Hui Yu, Mei-Ching Hsu, Chih-Cheng Lin, Ching-Yuang Mortality Risks among Various Primary Renal Diseases in Children and Adolescents on Chronic Dialysis |
title | Mortality Risks among Various Primary Renal Diseases in Children and Adolescents on Chronic Dialysis |
title_full | Mortality Risks among Various Primary Renal Diseases in Children and Adolescents on Chronic Dialysis |
title_fullStr | Mortality Risks among Various Primary Renal Diseases in Children and Adolescents on Chronic Dialysis |
title_full_unstemmed | Mortality Risks among Various Primary Renal Diseases in Children and Adolescents on Chronic Dialysis |
title_short | Mortality Risks among Various Primary Renal Diseases in Children and Adolescents on Chronic Dialysis |
title_sort | mortality risks among various primary renal diseases in children and adolescents on chronic dialysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262556/ https://www.ncbi.nlm.nih.gov/pubmed/30400589 http://dx.doi.org/10.3390/jcm7110414 |
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