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Rituximab and Fibrillary Glomerulonephritis: Interest of B Cell Reconstitution Monitoring

Fibrillary glomerulonephritis (FGN) is a rare glomerular disease characterized by glomerular deposition of randomly arranged non-amyloid fibrils. FGN has a poor renal prognosis and its optimal treatment is a medical challenge. Rituximab therapy has recently emerged as a promising approach even thoug...

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Detalles Bibliográficos
Autores principales: Leibler, Claire, Moktefi, Anissa, Matignon, Marie, Debiais-Delpech, Céline, Oniszczuk, Julie, Sahali, Dil, Cohen, José L., Grimbert, Philippe, Audard, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262590/
https://www.ncbi.nlm.nih.gov/pubmed/30423930
http://dx.doi.org/10.3390/jcm7110430
Descripción
Sumario:Fibrillary glomerulonephritis (FGN) is a rare glomerular disease characterized by glomerular deposition of randomly arranged non-amyloid fibrils. FGN has a poor renal prognosis and its optimal treatment is a medical challenge. Rituximab therapy has recently emerged as a promising approach even though its mechanism of action remains hypothetical. We describe the case of a 55-year-old woman with FGN successfully treated by rituximab. During the 36-month follow-up, she had three relapses of FGN, occurring each time in the context of B cell recovery. Investigation of the distribution of B cell subpopulations at the time of the third relapse showed, as previously described for some immunological diseases, an increase in the proportion of switched memory B cells relative to healthy subjects, whereas global memory B cell pool was not yet recovered. This case suggests that B cell reconstitution should be carefully monitored in the management of FGN treated with rituximab.