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Observational Study of Antibiotic Usage at the Children’s Clinical University Hospital in Riga, Latvia
Background and objectives: Many pediatric patients have been treated with antibiotics during their hospitalization. There is a need to improve antibiotic prescribing for pediatric patients because many of these prescriptions are inappropriate. Antibiotic consumption analysis was conducted at the Chi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262611/ https://www.ncbi.nlm.nih.gov/pubmed/30360478 http://dx.doi.org/10.3390/medicina54050074 |
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author | Sviestina, Inese Mozgis, Dzintars |
author_facet | Sviestina, Inese Mozgis, Dzintars |
author_sort | Sviestina, Inese |
collection | PubMed |
description | Background and objectives: Many pediatric patients have been treated with antibiotics during their hospitalization. There is a need to improve antibiotic prescribing for pediatric patients because many of these prescriptions are inappropriate. Antibiotic consumption analysis was conducted at the Children’s Clinical University Hospital to identify targets for quality improvement. Materials and Methods: A one day cross-sectional point prevalence survey (PPS) was conducted in May and November 2011–2013 using a previously validated and standardized method. The survey included all inpatient pediatric and neonatal beds and identified all children receiving an antibiotic treatment on the day of survey. Total consumption of systemic antibiotics belonging to the ATC J01 class (except amphenicols (J01B) and a combination of antibacterials (J01R)) was also analyzed by using a defined daily dose (DDD) approach and antibiotic drug utilization (90%DU) for the period 2006–2015. Results were compared with results in 2017 using the DDD and 90%DU methodology. Results: The most commonly used antibiotic group in all PPS, except in May and November 2011, was other β-lactam antibiotics (J01D): 42 (40%) prescriptions in May 2013 and 66 (42%) and November 2011. In 2006–2015 and also in 2017, the most commonly used antibiotic groups were penicillins (J01C) and other β-lactam antibiotics (J01D)—76% (90%DU) of the total antibiotic consumption registered in 2006, 73% in 2015 and 70% in 2017. Starting in 2008, amoxicillin was the most commonly used antibiotic at the hospital. The usage of ceftriaxone increased from 3% in 2006 to 13% in 2015, but decreased in 2017 (7%). Conclusions: Study results from 2006–2015 showed that there was a need to establish a stronger antibiotic prescribing policy in the hospital reducing the use of broad-spectrum antibiotics (especially 3rd generation cephalosporins) and increasing the use of narrower spectrum antibiotics. It was partly achieved in 2017 with some reduction in ceftriaxone use. |
format | Online Article Text |
id | pubmed-6262611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62626112018-12-05 Observational Study of Antibiotic Usage at the Children’s Clinical University Hospital in Riga, Latvia Sviestina, Inese Mozgis, Dzintars Medicina (Kaunas) Article Background and objectives: Many pediatric patients have been treated with antibiotics during their hospitalization. There is a need to improve antibiotic prescribing for pediatric patients because many of these prescriptions are inappropriate. Antibiotic consumption analysis was conducted at the Children’s Clinical University Hospital to identify targets for quality improvement. Materials and Methods: A one day cross-sectional point prevalence survey (PPS) was conducted in May and November 2011–2013 using a previously validated and standardized method. The survey included all inpatient pediatric and neonatal beds and identified all children receiving an antibiotic treatment on the day of survey. Total consumption of systemic antibiotics belonging to the ATC J01 class (except amphenicols (J01B) and a combination of antibacterials (J01R)) was also analyzed by using a defined daily dose (DDD) approach and antibiotic drug utilization (90%DU) for the period 2006–2015. Results were compared with results in 2017 using the DDD and 90%DU methodology. Results: The most commonly used antibiotic group in all PPS, except in May and November 2011, was other β-lactam antibiotics (J01D): 42 (40%) prescriptions in May 2013 and 66 (42%) and November 2011. In 2006–2015 and also in 2017, the most commonly used antibiotic groups were penicillins (J01C) and other β-lactam antibiotics (J01D)—76% (90%DU) of the total antibiotic consumption registered in 2006, 73% in 2015 and 70% in 2017. Starting in 2008, amoxicillin was the most commonly used antibiotic at the hospital. The usage of ceftriaxone increased from 3% in 2006 to 13% in 2015, but decreased in 2017 (7%). Conclusions: Study results from 2006–2015 showed that there was a need to establish a stronger antibiotic prescribing policy in the hospital reducing the use of broad-spectrum antibiotics (especially 3rd generation cephalosporins) and increasing the use of narrower spectrum antibiotics. It was partly achieved in 2017 with some reduction in ceftriaxone use. MDPI 2018-10-23 /pmc/articles/PMC6262611/ /pubmed/30360478 http://dx.doi.org/10.3390/medicina54050074 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sviestina, Inese Mozgis, Dzintars Observational Study of Antibiotic Usage at the Children’s Clinical University Hospital in Riga, Latvia |
title | Observational Study of Antibiotic Usage at the Children’s Clinical University Hospital in Riga, Latvia |
title_full | Observational Study of Antibiotic Usage at the Children’s Clinical University Hospital in Riga, Latvia |
title_fullStr | Observational Study of Antibiotic Usage at the Children’s Clinical University Hospital in Riga, Latvia |
title_full_unstemmed | Observational Study of Antibiotic Usage at the Children’s Clinical University Hospital in Riga, Latvia |
title_short | Observational Study of Antibiotic Usage at the Children’s Clinical University Hospital in Riga, Latvia |
title_sort | observational study of antibiotic usage at the children’s clinical university hospital in riga, latvia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262611/ https://www.ncbi.nlm.nih.gov/pubmed/30360478 http://dx.doi.org/10.3390/medicina54050074 |
work_keys_str_mv | AT sviestinainese observationalstudyofantibioticusageatthechildrensclinicaluniversityhospitalinrigalatvia AT mozgisdzintars observationalstudyofantibioticusageatthechildrensclinicaluniversityhospitalinrigalatvia |