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Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive Symptoms

Recent studies indicate that patients with depression have increased concentrations of serum pro-inflammatory cytokines. However, studies of IL-17 and studies on community-dwellers are few. The purpose of this study was to investigate serum cytokine levels, especially IL-17A, among subjects with hig...

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Autores principales: Tsuboi, Hirohito, Sakakibara, Hiroyuki, Minamida, Yuuki, Tsujiguchi, Hiromasa, Matsunaga, Masahiro, Hara, Akinori, Nakamura, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262626/
https://www.ncbi.nlm.nih.gov/pubmed/30400354
http://dx.doi.org/10.3390/bs8110102
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author Tsuboi, Hirohito
Sakakibara, Hiroyuki
Minamida, Yuuki
Tsujiguchi, Hiromasa
Matsunaga, Masahiro
Hara, Akinori
Nakamura, Hiroyuki
author_facet Tsuboi, Hirohito
Sakakibara, Hiroyuki
Minamida, Yuuki
Tsujiguchi, Hiromasa
Matsunaga, Masahiro
Hara, Akinori
Nakamura, Hiroyuki
author_sort Tsuboi, Hirohito
collection PubMed
description Recent studies indicate that patients with depression have increased concentrations of serum pro-inflammatory cytokines. However, studies of IL-17 and studies on community-dwellers are few. The purpose of this study was to investigate serum cytokine levels, especially IL-17A, among subjects with high and low depressive symptoms of a general population. The participants comprised 20 female community-dwellers aged 40 years or older who contributed to a Shika study in Ishikawa, Japan. Ten participants who showed higher and ten who showed lower depressive symptoms among 208 females assessed by the Japanese version of the Centre for Epidemiologic Studies Depression Scale (CES-D) were selected for this study. Serum samples were analyzed for TNF-alpha, IL-6, IL-10, IL-12, and IL-17A using a multiplex Luminex analysis. For the comparison between the high and low depressive groups statistically, linear regression analyses were applied. The serum level of IL-17A was significantly higher among the high depressive participants (p < 0.05) even after controlling possible confounders, whereas there were no differences in TNF-alpha, IL-6, IL-10, or IL-12 between the high and low depressive groups. Our findings supported an association between serum IL-17A levels and depressive symptoms. Peripheral IL-17A immune response may be a preventive and treatment target for depression.
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spelling pubmed-62626262018-11-29 Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive Symptoms Tsuboi, Hirohito Sakakibara, Hiroyuki Minamida, Yuuki Tsujiguchi, Hiromasa Matsunaga, Masahiro Hara, Akinori Nakamura, Hiroyuki Behav Sci (Basel) Article Recent studies indicate that patients with depression have increased concentrations of serum pro-inflammatory cytokines. However, studies of IL-17 and studies on community-dwellers are few. The purpose of this study was to investigate serum cytokine levels, especially IL-17A, among subjects with high and low depressive symptoms of a general population. The participants comprised 20 female community-dwellers aged 40 years or older who contributed to a Shika study in Ishikawa, Japan. Ten participants who showed higher and ten who showed lower depressive symptoms among 208 females assessed by the Japanese version of the Centre for Epidemiologic Studies Depression Scale (CES-D) were selected for this study. Serum samples were analyzed for TNF-alpha, IL-6, IL-10, IL-12, and IL-17A using a multiplex Luminex analysis. For the comparison between the high and low depressive groups statistically, linear regression analyses were applied. The serum level of IL-17A was significantly higher among the high depressive participants (p < 0.05) even after controlling possible confounders, whereas there were no differences in TNF-alpha, IL-6, IL-10, or IL-12 between the high and low depressive groups. Our findings supported an association between serum IL-17A levels and depressive symptoms. Peripheral IL-17A immune response may be a preventive and treatment target for depression. MDPI 2018-11-04 /pmc/articles/PMC6262626/ /pubmed/30400354 http://dx.doi.org/10.3390/bs8110102 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tsuboi, Hirohito
Sakakibara, Hiroyuki
Minamida, Yuuki
Tsujiguchi, Hiromasa
Matsunaga, Masahiro
Hara, Akinori
Nakamura, Hiroyuki
Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive Symptoms
title Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive Symptoms
title_full Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive Symptoms
title_fullStr Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive Symptoms
title_full_unstemmed Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive Symptoms
title_short Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive Symptoms
title_sort elevated levels of serum il-17a in community-dwelling women with higher depressive symptoms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262626/
https://www.ncbi.nlm.nih.gov/pubmed/30400354
http://dx.doi.org/10.3390/bs8110102
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