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The Role of Co-Stimulatory Molecules in Chagas Disease

Chagas disease, caused by Trypanosoma cruzi, is a potentially life-threatening tropical disease endemic to Latin American countries that affects approximately 8 million people. In the chronic phase of the disease, individuals are classified as belonging to the indeterminate clinical form or to the c...

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Autores principales: Pinto, Bruna F., Medeiros, Nayara I., Fontes-Cal, Tereza C. M., Naziazeno, Isabela M., Correa-Oliveira, Rodrigo, Dutra, Walderez O., Gomes, Juliana A. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262639/
https://www.ncbi.nlm.nih.gov/pubmed/30405039
http://dx.doi.org/10.3390/cells7110200
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author Pinto, Bruna F.
Medeiros, Nayara I.
Fontes-Cal, Tereza C. M.
Naziazeno, Isabela M.
Correa-Oliveira, Rodrigo
Dutra, Walderez O.
Gomes, Juliana A. S.
author_facet Pinto, Bruna F.
Medeiros, Nayara I.
Fontes-Cal, Tereza C. M.
Naziazeno, Isabela M.
Correa-Oliveira, Rodrigo
Dutra, Walderez O.
Gomes, Juliana A. S.
author_sort Pinto, Bruna F.
collection PubMed
description Chagas disease, caused by Trypanosoma cruzi, is a potentially life-threatening tropical disease endemic to Latin American countries that affects approximately 8 million people. In the chronic phase of the disease, individuals are classified as belonging to the indeterminate clinical form or to the cardiac and/or digestive forms when clinical symptoms are apparent. The relationship between monocytes and lymphocytes may be an important point to help clarify the complexity that surrounds the clinical symptoms of the chronic phase of Chagas disease. The co-stimulatory signals are essential to determining the magnitude of T cell response to the antigen. The signals are known to determine the regulation of subsequent adaptive immune response. However, little is known about the expression and function of these molecules in Chagas disease. Therefore, this review aims to discuss the possible role of main pathways of co-stimulatory molecule-receptor interactions in this pathology that could be crucial to understand the disease dynamics.
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spelling pubmed-62626392018-12-03 The Role of Co-Stimulatory Molecules in Chagas Disease Pinto, Bruna F. Medeiros, Nayara I. Fontes-Cal, Tereza C. M. Naziazeno, Isabela M. Correa-Oliveira, Rodrigo Dutra, Walderez O. Gomes, Juliana A. S. Cells Review Chagas disease, caused by Trypanosoma cruzi, is a potentially life-threatening tropical disease endemic to Latin American countries that affects approximately 8 million people. In the chronic phase of the disease, individuals are classified as belonging to the indeterminate clinical form or to the cardiac and/or digestive forms when clinical symptoms are apparent. The relationship between monocytes and lymphocytes may be an important point to help clarify the complexity that surrounds the clinical symptoms of the chronic phase of Chagas disease. The co-stimulatory signals are essential to determining the magnitude of T cell response to the antigen. The signals are known to determine the regulation of subsequent adaptive immune response. However, little is known about the expression and function of these molecules in Chagas disease. Therefore, this review aims to discuss the possible role of main pathways of co-stimulatory molecule-receptor interactions in this pathology that could be crucial to understand the disease dynamics. MDPI 2018-11-07 /pmc/articles/PMC6262639/ /pubmed/30405039 http://dx.doi.org/10.3390/cells7110200 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pinto, Bruna F.
Medeiros, Nayara I.
Fontes-Cal, Tereza C. M.
Naziazeno, Isabela M.
Correa-Oliveira, Rodrigo
Dutra, Walderez O.
Gomes, Juliana A. S.
The Role of Co-Stimulatory Molecules in Chagas Disease
title The Role of Co-Stimulatory Molecules in Chagas Disease
title_full The Role of Co-Stimulatory Molecules in Chagas Disease
title_fullStr The Role of Co-Stimulatory Molecules in Chagas Disease
title_full_unstemmed The Role of Co-Stimulatory Molecules in Chagas Disease
title_short The Role of Co-Stimulatory Molecules in Chagas Disease
title_sort role of co-stimulatory molecules in chagas disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262639/
https://www.ncbi.nlm.nih.gov/pubmed/30405039
http://dx.doi.org/10.3390/cells7110200
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