Cargando…
The Role of Co-Stimulatory Molecules in Chagas Disease
Chagas disease, caused by Trypanosoma cruzi, is a potentially life-threatening tropical disease endemic to Latin American countries that affects approximately 8 million people. In the chronic phase of the disease, individuals are classified as belonging to the indeterminate clinical form or to the c...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262639/ https://www.ncbi.nlm.nih.gov/pubmed/30405039 http://dx.doi.org/10.3390/cells7110200 |
_version_ | 1783375150646820864 |
---|---|
author | Pinto, Bruna F. Medeiros, Nayara I. Fontes-Cal, Tereza C. M. Naziazeno, Isabela M. Correa-Oliveira, Rodrigo Dutra, Walderez O. Gomes, Juliana A. S. |
author_facet | Pinto, Bruna F. Medeiros, Nayara I. Fontes-Cal, Tereza C. M. Naziazeno, Isabela M. Correa-Oliveira, Rodrigo Dutra, Walderez O. Gomes, Juliana A. S. |
author_sort | Pinto, Bruna F. |
collection | PubMed |
description | Chagas disease, caused by Trypanosoma cruzi, is a potentially life-threatening tropical disease endemic to Latin American countries that affects approximately 8 million people. In the chronic phase of the disease, individuals are classified as belonging to the indeterminate clinical form or to the cardiac and/or digestive forms when clinical symptoms are apparent. The relationship between monocytes and lymphocytes may be an important point to help clarify the complexity that surrounds the clinical symptoms of the chronic phase of Chagas disease. The co-stimulatory signals are essential to determining the magnitude of T cell response to the antigen. The signals are known to determine the regulation of subsequent adaptive immune response. However, little is known about the expression and function of these molecules in Chagas disease. Therefore, this review aims to discuss the possible role of main pathways of co-stimulatory molecule-receptor interactions in this pathology that could be crucial to understand the disease dynamics. |
format | Online Article Text |
id | pubmed-6262639 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62626392018-12-03 The Role of Co-Stimulatory Molecules in Chagas Disease Pinto, Bruna F. Medeiros, Nayara I. Fontes-Cal, Tereza C. M. Naziazeno, Isabela M. Correa-Oliveira, Rodrigo Dutra, Walderez O. Gomes, Juliana A. S. Cells Review Chagas disease, caused by Trypanosoma cruzi, is a potentially life-threatening tropical disease endemic to Latin American countries that affects approximately 8 million people. In the chronic phase of the disease, individuals are classified as belonging to the indeterminate clinical form or to the cardiac and/or digestive forms when clinical symptoms are apparent. The relationship between monocytes and lymphocytes may be an important point to help clarify the complexity that surrounds the clinical symptoms of the chronic phase of Chagas disease. The co-stimulatory signals are essential to determining the magnitude of T cell response to the antigen. The signals are known to determine the regulation of subsequent adaptive immune response. However, little is known about the expression and function of these molecules in Chagas disease. Therefore, this review aims to discuss the possible role of main pathways of co-stimulatory molecule-receptor interactions in this pathology that could be crucial to understand the disease dynamics. MDPI 2018-11-07 /pmc/articles/PMC6262639/ /pubmed/30405039 http://dx.doi.org/10.3390/cells7110200 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pinto, Bruna F. Medeiros, Nayara I. Fontes-Cal, Tereza C. M. Naziazeno, Isabela M. Correa-Oliveira, Rodrigo Dutra, Walderez O. Gomes, Juliana A. S. The Role of Co-Stimulatory Molecules in Chagas Disease |
title | The Role of Co-Stimulatory Molecules in Chagas Disease |
title_full | The Role of Co-Stimulatory Molecules in Chagas Disease |
title_fullStr | The Role of Co-Stimulatory Molecules in Chagas Disease |
title_full_unstemmed | The Role of Co-Stimulatory Molecules in Chagas Disease |
title_short | The Role of Co-Stimulatory Molecules in Chagas Disease |
title_sort | role of co-stimulatory molecules in chagas disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262639/ https://www.ncbi.nlm.nih.gov/pubmed/30405039 http://dx.doi.org/10.3390/cells7110200 |
work_keys_str_mv | AT pintobrunaf theroleofcostimulatorymoleculesinchagasdisease AT medeirosnayarai theroleofcostimulatorymoleculesinchagasdisease AT fontescalterezacm theroleofcostimulatorymoleculesinchagasdisease AT naziazenoisabelam theroleofcostimulatorymoleculesinchagasdisease AT correaoliveirarodrigo theroleofcostimulatorymoleculesinchagasdisease AT dutrawalderezo theroleofcostimulatorymoleculesinchagasdisease AT gomesjulianaas theroleofcostimulatorymoleculesinchagasdisease AT pintobrunaf roleofcostimulatorymoleculesinchagasdisease AT medeirosnayarai roleofcostimulatorymoleculesinchagasdisease AT fontescalterezacm roleofcostimulatorymoleculesinchagasdisease AT naziazenoisabelam roleofcostimulatorymoleculesinchagasdisease AT correaoliveirarodrigo roleofcostimulatorymoleculesinchagasdisease AT dutrawalderezo roleofcostimulatorymoleculesinchagasdisease AT gomesjulianaas roleofcostimulatorymoleculesinchagasdisease |