Recovery of Pure Red Cell Aplasia Following Hematopoietic Stem Cell Transplantation Associated with Interleukin (IL)-6 Elevation Caused by Odontogenic Infection

We herein report a case of long-lasting pure red cell aplasia (PRCA) after major ABO-incompatible allogeneic stem cell transplantation (SCT) for acute lymphoblastic leukemia. The patient needed red blood cell (RBC) transfusion every week after SCT. On day 236, he was diagnosed with odontogenic infec...

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Autores principales: Nakamura, Nobuhiko, Ninomiya, Soranobu, Matsumoto, Takuro, Nakamura, Hiroshi, Kitagawa, Junichi, Hara, Takeshi, Shimizu, Masahito, Tsurumi, Hisashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262699/
https://www.ncbi.nlm.nih.gov/pubmed/29877260
http://dx.doi.org/10.2169/internalmedicine.0869-18
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author Nakamura, Nobuhiko
Ninomiya, Soranobu
Matsumoto, Takuro
Nakamura, Hiroshi
Kitagawa, Junichi
Hara, Takeshi
Shimizu, Masahito
Tsurumi, Hisashi
author_facet Nakamura, Nobuhiko
Ninomiya, Soranobu
Matsumoto, Takuro
Nakamura, Hiroshi
Kitagawa, Junichi
Hara, Takeshi
Shimizu, Masahito
Tsurumi, Hisashi
author_sort Nakamura, Nobuhiko
collection PubMed
description We herein report a case of long-lasting pure red cell aplasia (PRCA) after major ABO-incompatible allogeneic stem cell transplantation (SCT) for acute lymphoblastic leukemia. The patient needed red blood cell (RBC) transfusion every week after SCT. On day 236, he was diagnosed with odontogenic infection, and the serum levels of Interleukin (IL)-6 were elevated to 12.1 pg/mL. After that, the numbers of reticulocyte rapidly began to increase, and RBC support was not needed from day 251. No standard care for PRCA following SCT has been established. The IL-6 elevation caused by the odontogenic infection therefore appears to have been affected by the improvement in PRCA.
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spelling pubmed-62626992018-11-30 Recovery of Pure Red Cell Aplasia Following Hematopoietic Stem Cell Transplantation Associated with Interleukin (IL)-6 Elevation Caused by Odontogenic Infection Nakamura, Nobuhiko Ninomiya, Soranobu Matsumoto, Takuro Nakamura, Hiroshi Kitagawa, Junichi Hara, Takeshi Shimizu, Masahito Tsurumi, Hisashi Intern Med Case Report We herein report a case of long-lasting pure red cell aplasia (PRCA) after major ABO-incompatible allogeneic stem cell transplantation (SCT) for acute lymphoblastic leukemia. The patient needed red blood cell (RBC) transfusion every week after SCT. On day 236, he was diagnosed with odontogenic infection, and the serum levels of Interleukin (IL)-6 were elevated to 12.1 pg/mL. After that, the numbers of reticulocyte rapidly began to increase, and RBC support was not needed from day 251. No standard care for PRCA following SCT has been established. The IL-6 elevation caused by the odontogenic infection therefore appears to have been affected by the improvement in PRCA. The Japanese Society of Internal Medicine 2018-06-06 2018-11-01 /pmc/articles/PMC6262699/ /pubmed/29877260 http://dx.doi.org/10.2169/internalmedicine.0869-18 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Nakamura, Nobuhiko
Ninomiya, Soranobu
Matsumoto, Takuro
Nakamura, Hiroshi
Kitagawa, Junichi
Hara, Takeshi
Shimizu, Masahito
Tsurumi, Hisashi
Recovery of Pure Red Cell Aplasia Following Hematopoietic Stem Cell Transplantation Associated with Interleukin (IL)-6 Elevation Caused by Odontogenic Infection
title Recovery of Pure Red Cell Aplasia Following Hematopoietic Stem Cell Transplantation Associated with Interleukin (IL)-6 Elevation Caused by Odontogenic Infection
title_full Recovery of Pure Red Cell Aplasia Following Hematopoietic Stem Cell Transplantation Associated with Interleukin (IL)-6 Elevation Caused by Odontogenic Infection
title_fullStr Recovery of Pure Red Cell Aplasia Following Hematopoietic Stem Cell Transplantation Associated with Interleukin (IL)-6 Elevation Caused by Odontogenic Infection
title_full_unstemmed Recovery of Pure Red Cell Aplasia Following Hematopoietic Stem Cell Transplantation Associated with Interleukin (IL)-6 Elevation Caused by Odontogenic Infection
title_short Recovery of Pure Red Cell Aplasia Following Hematopoietic Stem Cell Transplantation Associated with Interleukin (IL)-6 Elevation Caused by Odontogenic Infection
title_sort recovery of pure red cell aplasia following hematopoietic stem cell transplantation associated with interleukin (il)-6 elevation caused by odontogenic infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262699/
https://www.ncbi.nlm.nih.gov/pubmed/29877260
http://dx.doi.org/10.2169/internalmedicine.0869-18
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