The Analysis of Renal Infiltrating Cells in Acute Tubulointerstitial Nephritis Induced by Anti-PD-1 Antibodies: A Case Report and Review of the Literature

Nivolumab is an anti-programmed cell death-1 (PD-1) antibody that is utilized as an immune checkpoint inhibitor (ICI) for cancer therapy. We herein present the case of a 57-year-old man who developed acute kidney injury during treatment with nivolumab for lung cancer. A renal biopsy revealed acute t...

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Autores principales: Tabei, Akifumi, Watanabe, Mitsuharu, Ikeuchi, Hidekazu, Nakasatomi, Masao, Sakairi, Toru, Kaneko, Yoriaki, Maeshima, Akito, Kaira, Kyoichi, Hirato, Junko, Nojima, Yoshihisa, Hiromura, Keiju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262704/
https://www.ncbi.nlm.nih.gov/pubmed/29877267
http://dx.doi.org/10.2169/internalmedicine.0444-17
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author Tabei, Akifumi
Watanabe, Mitsuharu
Ikeuchi, Hidekazu
Nakasatomi, Masao
Sakairi, Toru
Kaneko, Yoriaki
Maeshima, Akito
Kaira, Kyoichi
Hirato, Junko
Nojima, Yoshihisa
Hiromura, Keiju
author_facet Tabei, Akifumi
Watanabe, Mitsuharu
Ikeuchi, Hidekazu
Nakasatomi, Masao
Sakairi, Toru
Kaneko, Yoriaki
Maeshima, Akito
Kaira, Kyoichi
Hirato, Junko
Nojima, Yoshihisa
Hiromura, Keiju
author_sort Tabei, Akifumi
collection PubMed
description Nivolumab is an anti-programmed cell death-1 (PD-1) antibody that is utilized as an immune checkpoint inhibitor (ICI) for cancer therapy. We herein present the case of a 57-year-old man who developed acute kidney injury during treatment with nivolumab for lung cancer. A renal biopsy revealed acute tubulointerstitial nephritis. Immunohistochemical staining demonstrated marked infiltration of macrophages and T cells together with mild B cell infiltration. Of note, strong CD163(+) M2 macrophage infiltration was observed. The cessation of nivolumab and high-dose prednisolone therapy improved the renal function of the patient. Further, we review the pertinent literature on renal-infiltrating cells in ICI-induced tubulointerstitial nephritis.
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spelling pubmed-62627042018-11-30 The Analysis of Renal Infiltrating Cells in Acute Tubulointerstitial Nephritis Induced by Anti-PD-1 Antibodies: A Case Report and Review of the Literature Tabei, Akifumi Watanabe, Mitsuharu Ikeuchi, Hidekazu Nakasatomi, Masao Sakairi, Toru Kaneko, Yoriaki Maeshima, Akito Kaira, Kyoichi Hirato, Junko Nojima, Yoshihisa Hiromura, Keiju Intern Med Case Report Nivolumab is an anti-programmed cell death-1 (PD-1) antibody that is utilized as an immune checkpoint inhibitor (ICI) for cancer therapy. We herein present the case of a 57-year-old man who developed acute kidney injury during treatment with nivolumab for lung cancer. A renal biopsy revealed acute tubulointerstitial nephritis. Immunohistochemical staining demonstrated marked infiltration of macrophages and T cells together with mild B cell infiltration. Of note, strong CD163(+) M2 macrophage infiltration was observed. The cessation of nivolumab and high-dose prednisolone therapy improved the renal function of the patient. Further, we review the pertinent literature on renal-infiltrating cells in ICI-induced tubulointerstitial nephritis. The Japanese Society of Internal Medicine 2018-06-06 2018-11-01 /pmc/articles/PMC6262704/ /pubmed/29877267 http://dx.doi.org/10.2169/internalmedicine.0444-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Tabei, Akifumi
Watanabe, Mitsuharu
Ikeuchi, Hidekazu
Nakasatomi, Masao
Sakairi, Toru
Kaneko, Yoriaki
Maeshima, Akito
Kaira, Kyoichi
Hirato, Junko
Nojima, Yoshihisa
Hiromura, Keiju
The Analysis of Renal Infiltrating Cells in Acute Tubulointerstitial Nephritis Induced by Anti-PD-1 Antibodies: A Case Report and Review of the Literature
title The Analysis of Renal Infiltrating Cells in Acute Tubulointerstitial Nephritis Induced by Anti-PD-1 Antibodies: A Case Report and Review of the Literature
title_full The Analysis of Renal Infiltrating Cells in Acute Tubulointerstitial Nephritis Induced by Anti-PD-1 Antibodies: A Case Report and Review of the Literature
title_fullStr The Analysis of Renal Infiltrating Cells in Acute Tubulointerstitial Nephritis Induced by Anti-PD-1 Antibodies: A Case Report and Review of the Literature
title_full_unstemmed The Analysis of Renal Infiltrating Cells in Acute Tubulointerstitial Nephritis Induced by Anti-PD-1 Antibodies: A Case Report and Review of the Literature
title_short The Analysis of Renal Infiltrating Cells in Acute Tubulointerstitial Nephritis Induced by Anti-PD-1 Antibodies: A Case Report and Review of the Literature
title_sort analysis of renal infiltrating cells in acute tubulointerstitial nephritis induced by anti-pd-1 antibodies: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262704/
https://www.ncbi.nlm.nih.gov/pubmed/29877267
http://dx.doi.org/10.2169/internalmedicine.0444-17
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