A 79-year-old Woman with Acute Hepatitis B Caused by the Infection of Subgenotype D1 Hepatitis B Virus in Japan: A Case Study

A 79-year-old Japanese woman was diagnosed with acute hepatitis B based on laboratory tests showing positivity for IgM-class antibody against hepatitis B virus (HBV) core and hepatitis B surface antigen (HBsAg) as well as elevated transaminases. A phylogenetic analysis revealed that the HBV strain o...

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Autores principales: Hashimoto, Kosei, Miura, Kouichi, Takaoka, Yoshinari, Nomoto, Hiroaki, Watanabe, Shunji, Tsukui, Mamiko, Morimoto, Naoki, Isoda, Norio, Nagashima, Shigeo, Takahashi, Masaharu, Okamoto, Hiroaki, Yamamoto, Hironori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262716/
https://www.ncbi.nlm.nih.gov/pubmed/29877273
http://dx.doi.org/10.2169/internalmedicine.0977-18
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author Hashimoto, Kosei
Miura, Kouichi
Takaoka, Yoshinari
Nomoto, Hiroaki
Watanabe, Shunji
Tsukui, Mamiko
Morimoto, Naoki
Isoda, Norio
Nagashima, Shigeo
Takahashi, Masaharu
Okamoto, Hiroaki
Yamamoto, Hironori
author_facet Hashimoto, Kosei
Miura, Kouichi
Takaoka, Yoshinari
Nomoto, Hiroaki
Watanabe, Shunji
Tsukui, Mamiko
Morimoto, Naoki
Isoda, Norio
Nagashima, Shigeo
Takahashi, Masaharu
Okamoto, Hiroaki
Yamamoto, Hironori
author_sort Hashimoto, Kosei
collection PubMed
description A 79-year-old Japanese woman was diagnosed with acute hepatitis B based on laboratory tests showing positivity for IgM-class antibody against hepatitis B virus (HBV) core and hepatitis B surface antigen (HBsAg) as well as elevated transaminases. A phylogenetic analysis revealed that the HBV strain obtained from the patient belonged to genotype D/subgenotype D1, similar to strains circulating in foreign countries but different from those in Japan. The clinical course was favorable. HBsAg became negative within 10 weeks after the onset. To our knowledge, this is the first report of acute hepatitis B caused by subgenotype D1 HBV in Japan.
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spelling pubmed-62627162018-11-30 A 79-year-old Woman with Acute Hepatitis B Caused by the Infection of Subgenotype D1 Hepatitis B Virus in Japan: A Case Study Hashimoto, Kosei Miura, Kouichi Takaoka, Yoshinari Nomoto, Hiroaki Watanabe, Shunji Tsukui, Mamiko Morimoto, Naoki Isoda, Norio Nagashima, Shigeo Takahashi, Masaharu Okamoto, Hiroaki Yamamoto, Hironori Intern Med Case Report A 79-year-old Japanese woman was diagnosed with acute hepatitis B based on laboratory tests showing positivity for IgM-class antibody against hepatitis B virus (HBV) core and hepatitis B surface antigen (HBsAg) as well as elevated transaminases. A phylogenetic analysis revealed that the HBV strain obtained from the patient belonged to genotype D/subgenotype D1, similar to strains circulating in foreign countries but different from those in Japan. The clinical course was favorable. HBsAg became negative within 10 weeks after the onset. To our knowledge, this is the first report of acute hepatitis B caused by subgenotype D1 HBV in Japan. The Japanese Society of Internal Medicine 2018-06-06 2018-11-01 /pmc/articles/PMC6262716/ /pubmed/29877273 http://dx.doi.org/10.2169/internalmedicine.0977-18 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hashimoto, Kosei
Miura, Kouichi
Takaoka, Yoshinari
Nomoto, Hiroaki
Watanabe, Shunji
Tsukui, Mamiko
Morimoto, Naoki
Isoda, Norio
Nagashima, Shigeo
Takahashi, Masaharu
Okamoto, Hiroaki
Yamamoto, Hironori
A 79-year-old Woman with Acute Hepatitis B Caused by the Infection of Subgenotype D1 Hepatitis B Virus in Japan: A Case Study
title A 79-year-old Woman with Acute Hepatitis B Caused by the Infection of Subgenotype D1 Hepatitis B Virus in Japan: A Case Study
title_full A 79-year-old Woman with Acute Hepatitis B Caused by the Infection of Subgenotype D1 Hepatitis B Virus in Japan: A Case Study
title_fullStr A 79-year-old Woman with Acute Hepatitis B Caused by the Infection of Subgenotype D1 Hepatitis B Virus in Japan: A Case Study
title_full_unstemmed A 79-year-old Woman with Acute Hepatitis B Caused by the Infection of Subgenotype D1 Hepatitis B Virus in Japan: A Case Study
title_short A 79-year-old Woman with Acute Hepatitis B Caused by the Infection of Subgenotype D1 Hepatitis B Virus in Japan: A Case Study
title_sort 79-year-old woman with acute hepatitis b caused by the infection of subgenotype d1 hepatitis b virus in japan: a case study
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262716/
https://www.ncbi.nlm.nih.gov/pubmed/29877273
http://dx.doi.org/10.2169/internalmedicine.0977-18
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