Nuclear Protein in Testis Carcinoma of the Thorax

Nuclear protein in testis (NUT) carcinoma (NUT-C) is an exceedingly rare and aggressive neoplasm. We herein report a case of a 57-year-old man with a rapidly progressing tumor of the thorax and left pleural effusion. The pathological features and immunohistochemical staining of specimens obtained by...

Descripción completa

Detalles Bibliográficos
Autores principales: Maruyama, Naomi, Hikiishi, Atsuhito, Suginaka, Miho, Furukawa, Koichi, Ogawa, Koichi, Nakamura, Naoki, Yoshida, Yae, Takata, Munetake, Nishijima, Masayoshi, Otani, Kenichiro, Kamimori, Takao, Fujiwara, Hiroshi, Yoshimatsu, Yuki, Ueda, Kayo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262720/
https://www.ncbi.nlm.nih.gov/pubmed/29877266
http://dx.doi.org/10.2169/internalmedicine.0434-17
Descripción
Sumario:Nuclear protein in testis (NUT) carcinoma (NUT-C) is an exceedingly rare and aggressive neoplasm. We herein report a case of a 57-year-old man with a rapidly progressing tumor of the thorax and left pleural effusion. The pathological features and immunohistochemical staining of specimens obtained by a transbronchial lung biopsy initially indicated poorly differentiated squamous cell carcinoma. However, given the clinical presentation along with the additional histopathologic features, NUT-C was considered. Immunohistochemical staining for NUT was positive in the pleural fluid cell block, confirming the diagnosis of NUT-C. This report indicates the utility of immunohistochemical staining for diagnosing NUT in the pleural fluid cell block.

Ejemplares similares