Nuclear Protein in Testis Carcinoma of the Thorax

Nuclear protein in testis (NUT) carcinoma (NUT-C) is an exceedingly rare and aggressive neoplasm. We herein report a case of a 57-year-old man with a rapidly progressing tumor of the thorax and left pleural effusion. The pathological features and immunohistochemical staining of specimens obtained by...

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Autores principales: Maruyama, Naomi, Hikiishi, Atsuhito, Suginaka, Miho, Furukawa, Koichi, Ogawa, Koichi, Nakamura, Naoki, Yoshida, Yae, Takata, Munetake, Nishijima, Masayoshi, Otani, Kenichiro, Kamimori, Takao, Fujiwara, Hiroshi, Yoshimatsu, Yuki, Ueda, Kayo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262720/
https://www.ncbi.nlm.nih.gov/pubmed/29877266
http://dx.doi.org/10.2169/internalmedicine.0434-17
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author Maruyama, Naomi
Hikiishi, Atsuhito
Suginaka, Miho
Furukawa, Koichi
Ogawa, Koichi
Nakamura, Naoki
Yoshida, Yae
Takata, Munetake
Nishijima, Masayoshi
Otani, Kenichiro
Kamimori, Takao
Fujiwara, Hiroshi
Yoshimatsu, Yuki
Ueda, Kayo
author_facet Maruyama, Naomi
Hikiishi, Atsuhito
Suginaka, Miho
Furukawa, Koichi
Ogawa, Koichi
Nakamura, Naoki
Yoshida, Yae
Takata, Munetake
Nishijima, Masayoshi
Otani, Kenichiro
Kamimori, Takao
Fujiwara, Hiroshi
Yoshimatsu, Yuki
Ueda, Kayo
author_sort Maruyama, Naomi
collection PubMed
description Nuclear protein in testis (NUT) carcinoma (NUT-C) is an exceedingly rare and aggressive neoplasm. We herein report a case of a 57-year-old man with a rapidly progressing tumor of the thorax and left pleural effusion. The pathological features and immunohistochemical staining of specimens obtained by a transbronchial lung biopsy initially indicated poorly differentiated squamous cell carcinoma. However, given the clinical presentation along with the additional histopathologic features, NUT-C was considered. Immunohistochemical staining for NUT was positive in the pleural fluid cell block, confirming the diagnosis of NUT-C. This report indicates the utility of immunohistochemical staining for diagnosing NUT in the pleural fluid cell block.
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spelling pubmed-62627202018-11-30 Nuclear Protein in Testis Carcinoma of the Thorax Maruyama, Naomi Hikiishi, Atsuhito Suginaka, Miho Furukawa, Koichi Ogawa, Koichi Nakamura, Naoki Yoshida, Yae Takata, Munetake Nishijima, Masayoshi Otani, Kenichiro Kamimori, Takao Fujiwara, Hiroshi Yoshimatsu, Yuki Ueda, Kayo Intern Med Case Report Nuclear protein in testis (NUT) carcinoma (NUT-C) is an exceedingly rare and aggressive neoplasm. We herein report a case of a 57-year-old man with a rapidly progressing tumor of the thorax and left pleural effusion. The pathological features and immunohistochemical staining of specimens obtained by a transbronchial lung biopsy initially indicated poorly differentiated squamous cell carcinoma. However, given the clinical presentation along with the additional histopathologic features, NUT-C was considered. Immunohistochemical staining for NUT was positive in the pleural fluid cell block, confirming the diagnosis of NUT-C. This report indicates the utility of immunohistochemical staining for diagnosing NUT in the pleural fluid cell block. The Japanese Society of Internal Medicine 2018-06-06 2018-11-01 /pmc/articles/PMC6262720/ /pubmed/29877266 http://dx.doi.org/10.2169/internalmedicine.0434-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Maruyama, Naomi
Hikiishi, Atsuhito
Suginaka, Miho
Furukawa, Koichi
Ogawa, Koichi
Nakamura, Naoki
Yoshida, Yae
Takata, Munetake
Nishijima, Masayoshi
Otani, Kenichiro
Kamimori, Takao
Fujiwara, Hiroshi
Yoshimatsu, Yuki
Ueda, Kayo
Nuclear Protein in Testis Carcinoma of the Thorax
title Nuclear Protein in Testis Carcinoma of the Thorax
title_full Nuclear Protein in Testis Carcinoma of the Thorax
title_fullStr Nuclear Protein in Testis Carcinoma of the Thorax
title_full_unstemmed Nuclear Protein in Testis Carcinoma of the Thorax
title_short Nuclear Protein in Testis Carcinoma of the Thorax
title_sort nuclear protein in testis carcinoma of the thorax
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262720/
https://www.ncbi.nlm.nih.gov/pubmed/29877266
http://dx.doi.org/10.2169/internalmedicine.0434-17
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