A novel mutation in the NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4 (Ndufa4) gene links mitochondrial dysfunction to the development of diabetes in a rodent model

The mechanisms underlying diabetes remain unresolved. The Cohen diabetic rat represents a model of diet-induced diabetes, in which the disease is induced after exposure to a diabetogenic diet (DD) in the diabetes-sensitive (CDs/y) but not in the -resistant (CDr/y) strain. Diet imposes a metabolic st...

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Detalles Bibliográficos
Autores principales: Yagil, Chana, Varadi-Levi, Ronen, Yagil, Yoram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262808/
https://www.ncbi.nlm.nih.gov/pubmed/30361421
http://dx.doi.org/10.1242/dmm.036699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262808/
https://www.ncbi.nlm.nih.gov/pubmed/30361421
http://dx.doi.org/10.1242/dmm.036699

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