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Overexpression of Fgfr2c causes craniofacial bone hypoplasia and ameliorates craniosynostosis in the Crouzon mouse

FGFR2c regulates many aspects of craniofacial and skeletal development. Mutations in the FGFR2 gene are causative of multiple forms of syndromic craniosynostosis, including Crouzon syndrome. Paradoxically, mouse studies have shown that the activation (Fgfr2c(C342Y); a mouse model for human Crouzon s...

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Detalles Bibliográficos
Autores principales:	Lee, Kevin K. L., Peskett, Emma, Quinn, Charlotte M., Aiello, Rosanna, Adeeva, Liliya, Moulding, Dale A., Stanier, Philip, Pauws, Erwin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262810/ https://www.ncbi.nlm.nih.gov/pubmed/30266836 http://dx.doi.org/10.1242/dmm.035311

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