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Interspecies transmission to bovinized transgenic mice uncovers new features of a CH1641-like scrapie isolate

In animal prion diseases, including bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease in cervids, and scrapie in sheep and goats, a disease-associated isoform of prion protein (PrP(d)) accumulates in the brains of affected animals. Although the CH1641 scrapie isolate was expe...

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Detalles Bibliográficos
Autores principales: Miyazawa, Kohtaro, Masujin, Kentaro, Matsuura, Yuichi, Iwamaru, Yoshifumi, Yokoyama, Takashi, Okada, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262972/
https://www.ncbi.nlm.nih.gov/pubmed/30486902
http://dx.doi.org/10.1186/s13567-018-0611-1