Cargando…

Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer’s disease therapy

In view of the multifactorial nature of Alzheimer’s disease (AD), multitarget small molecules (MTSM) represent the most potent and attractive therapeutic strategy to design new drugs for Alzheimer’s disease therapy. The new MTSM KojoTacrines (KTs) were designed and synthesized by juxtaposition of se...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dgachi, Youssef, Martin, Hélène, Malek, Rim, Jun, Daniel, Janockova, Jana, Sepsova, Vendula, Soukup, Ondrej, Iriepa, Isabel, Moraleda, Ignacio, Maalej, Emna, Carreiras, M. Carmo, Refouvelet, Bernard, Chabchoub, Fakher, Marco-Contelles, José, Ismaili, Lhassane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263107/ https://www.ncbi.nlm.nih.gov/pubmed/30482062 http://dx.doi.org/10.1080/14756366.2018.1538136

Ejemplares similares

Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer’s Disease
por: Dgachi, Youssef, et al.
Publicado: (2016)

Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer’s Agents: Design, Synthesis and Biological Evaluation
por: Spilovska, Katarina, et al.
Publicado: (2017)

Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer’s Disease Therapy
por: Zribi, Lazhar, et al.
Publicado: (2020)

Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer’s Disease Treatment
por: Dakhlaoui, Imen, et al.
Publicado: (2023)

Benzochromenopyrimidines: Synthesis, Antiproliferative Activity against Colorectal Cancer and Physicochemical Properties
por: Choura, Emna, et al.
Publicado: (2022)

Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy
por: Pachón-Angona, Irene, et al.
Publicado: (2019)

Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives
por: Pachón Angona, Irene, et al.
Publicado: (2020)

Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities
por: Chrienova, Zofia, et al.
Publicado: (2022)

Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors
por: Svobodova, Barbora, et al.
Publicado: (2019)

QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer’s Disease Therapy
por: Ramos, Eva, et al.
Publicado: (2019)

The Proof-of-Concept of MBA121, a Tacrine–Ferulic Acid Hybrid, for Alzheimer’s Disease Therapy
por: Rodríguez-Ruiz, Emelina R., et al.
Publicado: (2023)

In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers
por: Janockova, Jana, et al.
Publicado: (2019)

Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca(2+) Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation
por: Malek, Rim, et al.
Publicado: (2022)

Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer′s Disease Therapy
por: Boulebd, Houssem, et al.
Publicado: (2016)

ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy
por: Marco-Contelles, José, et al.
Publicado: (2016)

Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer’s Disease Therapy
por: Bautista-Aguilera, Óscar M., et al.
Publicado: (2020)

Pharmacophore Modelling and Synthesis of Quinoline-3-Carbohydrazide as Antioxidants
por: El Bakkali, Mustapha, et al.
Publicado: (2011)

Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels
por: Pachòn Angona, Irene, et al.
Publicado: (2020)

Therapeutic Potential of Multifunctional Tacrine Analogues
por: Przybyłowska, Maja, et al.
Publicado: (2019)

Editorial: Advances in drug discovery for anti-Alzheimer’s agents
por: Ismaili, Lhassane
Publicado: (2022)

QSAR analysis on tacrine-related acetylcholinesterase inhibitors
por: Wong, Kai Y, et al.
Publicado: (2014)

Tacrine-Based Hybrids: Past, Present, and Future
por: Bubley, Anna, et al.
Publicado: (2023)

Formulation, Characterization and Evaluation against SH-SY5Y Cells of New Tacrine and Tacrine-MAP Loaded with Lipid Nanoparticles
por: Silva, Sara, et al.
Publicado: (2020)

Synthesis and Antioxidant Properties of HeteroBisNitrones Derived from Benzene Dicarbaldehydes
por: Diez-Iriepa, Daniel, et al.
Publicado: (2022)

Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods
por: Janockova, Jana, et al.
Publicado: (2018)

Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase
por: Evangelista, Tereza Cristina Santos, et al.
Publicado: (2021)

Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease
por: Grishchenko, Maria V., et al.
Publicado: (2022)

7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment
por: Korabecny, Jan, et al.
Publicado: (2015)

Acetylcholinesterase Reactivators (HI-6, Obidoxime, Trimedoxime, K027, K075, K127, K203, K282): Structural Evaluation of Human Serum Albumin Binding and Absorption Kinetics
por: Zemek, Filip, et al.
Publicado: (2013)

Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings
por: Kuca, Kamil, et al.
Publicado: (2018)

Mechanism of Tacrine Block at Adult Human Muscle Nicotinic Acetylcholine Receptors
por: Prince, Richard J., et al.
Publicado: (2002)

The Investigation of Structure-Activity Relationships of Tacrine Analogues: Electronic-Topological Method
por: Saracoglu, Murat, et al.
Publicado: (2008)

New Tacrine Analogs as Acetylcholinesterase Inhibitors — Theoretical Study with Chemometric Analysis
por: Szymański, Paweł, et al.
Publicado: (2013)

Effect of Donepezil, Tacrine, Galantamine and Rivastigmine on Acetylcholinesterase Inhibition in Dugesia tigrina
por: Bezerra da Silva, Cristiane, et al.
Publicado: (2016)

Model Amphipathic Peptide Coupled with Tacrine to Improve Its Antiproliferative Activity
por: Silva, Sara, et al.
Publicado: (2020)

Tacrine Derivatives in Neurological Disorders: Focus on Molecular Mechanisms and Neurotherapeutic Potential
por: Mitra, Saikat, et al.
Publicado: (2022)

Investigation of the enantioselectivity of acetylcholinesterase and butyrylcholinesterase upon inhibition by tacrine-iminosugar heterodimers
por: Vaaland, I. Caroline, et al.
Publicado: (2022)

Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids
por: Bautista-Aguilera, Oscar M, et al.
Publicado: (2014)

Neuroactive Multifunctional Tacrine Congeners with Cholinesterase, Anti-Amyloid Aggregation and Neuroprotective Properties
por: Kozurkova, Maria, et al.
Publicado: (2011)

Electroacupuncture at PC6 or ST36 Influences the Effect of Tacrine on the Motility of Esophagus
por: Wang, Chi, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_3ci7b9eajon71q863hruup9e7o