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Dual-modified natural high density lipoprotein particles for systemic glioma-targeting drug delivery

Therapeutic outcome for the treatment of glioma was often limited due to the two barriers involved: the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB). Therefore, the development of nanocarriers that possess both BBB and BBTB permeability and glioma-targeting ability is of great impo...

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Autores principales: Cui, Lin, Wang, Yuli, Liang, Meng, Chu, Xiaoyang, Fu, Shiyao, Gao, Chunsheng, Liu, Qianqian, Gong, Wei, Yang, Meiyan, Li, Zhiping, Yu, Lian, Yang, Chunrong, Su, Zhide, Xie, Xiangyang, Yang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263114/
https://www.ncbi.nlm.nih.gov/pubmed/30474437
http://dx.doi.org/10.1080/10717544.2018.1519002
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author Cui, Lin
Wang, Yuli
Liang, Meng
Chu, Xiaoyang
Fu, Shiyao
Gao, Chunsheng
Liu, Qianqian
Gong, Wei
Yang, Meiyan
Li, Zhiping
Yu, Lian
Yang, Chunrong
Su, Zhide
Xie, Xiangyang
Yang, Yang
Gao, Chunsheng
author_facet Cui, Lin
Wang, Yuli
Liang, Meng
Chu, Xiaoyang
Fu, Shiyao
Gao, Chunsheng
Liu, Qianqian
Gong, Wei
Yang, Meiyan
Li, Zhiping
Yu, Lian
Yang, Chunrong
Su, Zhide
Xie, Xiangyang
Yang, Yang
Gao, Chunsheng
author_sort Cui, Lin
collection PubMed
description Therapeutic outcome for the treatment of glioma was often limited due to the two barriers involved: the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB). Therefore, the development of nanocarriers that possess both BBB and BBTB permeability and glioma-targeting ability is of great importance for the chemotherapy of glioma. New frontiers in nanomedicine are advancing the research of new biomaterials. Here we constructed a natural high-density lipoprotein particle (HDL)-based drug delivery system with the dual-modification of T7 and (d)A7R peptide ligand (T7/(d)A7R-HDL) to achieve the above goals. HDL, the smallest lipoprotein, plays a biological role and is highly suitable as a platform for delivering imaging and therapeutic agents. T7 is a seven-peptide ligand of transferrin receptors (TfR) capable of circumventing the BBB and then targeting glioma. (d)A7R is a d-peptide ligand of vascular endothelial growth factor receptor 2 (VEGFR 2) overexpressed on angiogenesis, presenting excellent glioma-homing property. 10-Hydroxycamptothecin (HCPT), a hydrophobic anti-cancer drug, was used as the model drug in this study. By combining the dual-targeting delivery effect, the dual-modified HDL displayed higher glioma localization than that of single ligand-modified HDL or free HCPT. After loading with HCPT, T7/(d)A7R-HDL showed the most favorable anti-glioma effect in vivo. These results demonstrated that the dual-targeting natural nanocarriers strategy provides a potential method for improving brain drug delivery and anti-glioma treatment efficacy.
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spelling pubmed-62631142018-12-04 Dual-modified natural high density lipoprotein particles for systemic glioma-targeting drug delivery Cui, Lin Wang, Yuli Liang, Meng Chu, Xiaoyang Fu, Shiyao Gao, Chunsheng Liu, Qianqian Gong, Wei Yang, Meiyan Li, Zhiping Yu, Lian Yang, Chunrong Su, Zhide Xie, Xiangyang Yang, Yang Gao, Chunsheng Drug Deliv Research Article Therapeutic outcome for the treatment of glioma was often limited due to the two barriers involved: the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB). Therefore, the development of nanocarriers that possess both BBB and BBTB permeability and glioma-targeting ability is of great importance for the chemotherapy of glioma. New frontiers in nanomedicine are advancing the research of new biomaterials. Here we constructed a natural high-density lipoprotein particle (HDL)-based drug delivery system with the dual-modification of T7 and (d)A7R peptide ligand (T7/(d)A7R-HDL) to achieve the above goals. HDL, the smallest lipoprotein, plays a biological role and is highly suitable as a platform for delivering imaging and therapeutic agents. T7 is a seven-peptide ligand of transferrin receptors (TfR) capable of circumventing the BBB and then targeting glioma. (d)A7R is a d-peptide ligand of vascular endothelial growth factor receptor 2 (VEGFR 2) overexpressed on angiogenesis, presenting excellent glioma-homing property. 10-Hydroxycamptothecin (HCPT), a hydrophobic anti-cancer drug, was used as the model drug in this study. By combining the dual-targeting delivery effect, the dual-modified HDL displayed higher glioma localization than that of single ligand-modified HDL or free HCPT. After loading with HCPT, T7/(d)A7R-HDL showed the most favorable anti-glioma effect in vivo. These results demonstrated that the dual-targeting natural nanocarriers strategy provides a potential method for improving brain drug delivery and anti-glioma treatment efficacy. Taylor & Francis 2018-11-26 /pmc/articles/PMC6263114/ /pubmed/30474437 http://dx.doi.org/10.1080/10717544.2018.1519002 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cui, Lin
Wang, Yuli
Liang, Meng
Chu, Xiaoyang
Fu, Shiyao
Gao, Chunsheng
Liu, Qianqian
Gong, Wei
Yang, Meiyan
Li, Zhiping
Yu, Lian
Yang, Chunrong
Su, Zhide
Xie, Xiangyang
Yang, Yang
Gao, Chunsheng
Dual-modified natural high density lipoprotein particles for systemic glioma-targeting drug delivery
title Dual-modified natural high density lipoprotein particles for systemic glioma-targeting drug delivery
title_full Dual-modified natural high density lipoprotein particles for systemic glioma-targeting drug delivery
title_fullStr Dual-modified natural high density lipoprotein particles for systemic glioma-targeting drug delivery
title_full_unstemmed Dual-modified natural high density lipoprotein particles for systemic glioma-targeting drug delivery
title_short Dual-modified natural high density lipoprotein particles for systemic glioma-targeting drug delivery
title_sort dual-modified natural high density lipoprotein particles for systemic glioma-targeting drug delivery
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263114/
https://www.ncbi.nlm.nih.gov/pubmed/30474437
http://dx.doi.org/10.1080/10717544.2018.1519002
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