Synthesis and Crystal Structure of Novel Sulfone Derivatives Containing 1,2,4-Triazole Moieties

Some 3-(Substituted methylthio)-4-phenyl-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazole derivatives were synthesized in six steps starting from easily accessible gallic acid. The resulting sulfides were then catalytically oxidized to the title sulfones with H(2)O(2). The products were obtained in high...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Weiming, Song,  Baoan, Bhadury, Pinaki, Song, Yang, Hu, Deyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263190/
https://www.ncbi.nlm.nih.gov/pubmed/20335944
http://dx.doi.org/10.3390/molecules15020766
_version_ 1783375242033364992
author Xu, Weiming
Song,  Baoan
Bhadury, Pinaki
Song, Yang
Hu, Deyu
author_facet Xu, Weiming
Song,  Baoan
Bhadury, Pinaki
Song, Yang
Hu, Deyu
author_sort Xu, Weiming
collection PubMed
description Some 3-(Substituted methylthio)-4-phenyl-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazole derivatives were synthesized in six steps starting from easily accessible gallic acid. The resulting sulfides were then catalytically oxidized to the title sulfones with H(2)O(2). The products were obtained in high yield under mild conditions and practically devoid of any by-products. The structures were confirmed by elemental analysis, IR, (1)H- and (13)C-NMR spectral data. Furthermore, a detailed X-ray crystallography structural analysis of model triazole 7g was carried out.
format Online
Article
Text
id pubmed-6263190
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Molecular Diversity Preservation International
record_format MEDLINE/PubMed
spelling pubmed-62631902018-12-03 Synthesis and Crystal Structure of Novel Sulfone Derivatives Containing 1,2,4-Triazole Moieties Xu, Weiming Song,  Baoan Bhadury, Pinaki Song, Yang Hu, Deyu Molecules Article Some 3-(Substituted methylthio)-4-phenyl-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazole derivatives were synthesized in six steps starting from easily accessible gallic acid. The resulting sulfides were then catalytically oxidized to the title sulfones with H(2)O(2). The products were obtained in high yield under mild conditions and practically devoid of any by-products. The structures were confirmed by elemental analysis, IR, (1)H- and (13)C-NMR spectral data. Furthermore, a detailed X-ray crystallography structural analysis of model triazole 7g was carried out. Molecular Diversity Preservation International 2010-02-03 /pmc/articles/PMC6263190/ /pubmed/20335944 http://dx.doi.org/10.3390/molecules15020766 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Xu, Weiming
Song,  Baoan
Bhadury, Pinaki
Song, Yang
Hu, Deyu
Synthesis and Crystal Structure of Novel Sulfone Derivatives Containing 1,2,4-Triazole Moieties
title Synthesis and Crystal Structure of Novel Sulfone Derivatives Containing 1,2,4-Triazole Moieties
title_full Synthesis and Crystal Structure of Novel Sulfone Derivatives Containing 1,2,4-Triazole Moieties
title_fullStr Synthesis and Crystal Structure of Novel Sulfone Derivatives Containing 1,2,4-Triazole Moieties
title_full_unstemmed Synthesis and Crystal Structure of Novel Sulfone Derivatives Containing 1,2,4-Triazole Moieties
title_short Synthesis and Crystal Structure of Novel Sulfone Derivatives Containing 1,2,4-Triazole Moieties
title_sort synthesis and crystal structure of novel sulfone derivatives containing 1,2,4-triazole moieties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263190/
https://www.ncbi.nlm.nih.gov/pubmed/20335944
http://dx.doi.org/10.3390/molecules15020766
work_keys_str_mv AT xuweiming synthesisandcrystalstructureofnovelsulfonederivativescontaining124triazolemoieties
AT songbaoan synthesisandcrystalstructureofnovelsulfonederivativescontaining124triazolemoieties
AT bhadurypinaki synthesisandcrystalstructureofnovelsulfonederivativescontaining124triazolemoieties
AT songyang synthesisandcrystalstructureofnovelsulfonederivativescontaining124triazolemoieties
AT hudeyu synthesisandcrystalstructureofnovelsulfonederivativescontaining124triazolemoieties

Ejemplares similares