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3-Nitropropionic Acid as a Tool to Study the Mechanisms Involved in Huntington’s Disease: Past, Present and Future

Huntington’s disease (HD) is an inheritable autosomal-dominant disorder whose causal mechanisms remain unknown. Experimental models have begun to uncover these pathways, thus helping to understand the mechanisms implicated and allowing for the characterization of potential targets for new therapeuti...

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Autores principales: Túnez, Isaac, Tasset, Inmaculada, Pérez-De La Cruz, Verónica, Santamaría, Abel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263191/
https://www.ncbi.nlm.nih.gov/pubmed/20335954
http://dx.doi.org/10.3390/molecules15020878
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author Túnez, Isaac
Tasset, Inmaculada
Pérez-De La Cruz, Verónica
Santamaría, Abel
author_facet Túnez, Isaac
Tasset, Inmaculada
Pérez-De La Cruz, Verónica
Santamaría, Abel
author_sort Túnez, Isaac
collection PubMed
description Huntington’s disease (HD) is an inheritable autosomal-dominant disorder whose causal mechanisms remain unknown. Experimental models have begun to uncover these pathways, thus helping to understand the mechanisms implicated and allowing for the characterization of potential targets for new therapeutic strategies. 3-Nitropropionic acid is known to produce in animals behavioural, biochemical and morphologic changes similar to those occurring in HD. For this reason, this phenotypic model is gaining attention as a valuable tool to mimick this disorder and further developing new therapies. In this review, we will focus on the past and present research of this molecule, to finally bring a perspective on what will be next in this promising field of study.
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spelling pubmed-62631912018-12-03 3-Nitropropionic Acid as a Tool to Study the Mechanisms Involved in Huntington’s Disease: Past, Present and Future Túnez, Isaac Tasset, Inmaculada Pérez-De La Cruz, Verónica Santamaría, Abel Molecules Review Huntington’s disease (HD) is an inheritable autosomal-dominant disorder whose causal mechanisms remain unknown. Experimental models have begun to uncover these pathways, thus helping to understand the mechanisms implicated and allowing for the characterization of potential targets for new therapeutic strategies. 3-Nitropropionic acid is known to produce in animals behavioural, biochemical and morphologic changes similar to those occurring in HD. For this reason, this phenotypic model is gaining attention as a valuable tool to mimick this disorder and further developing new therapies. In this review, we will focus on the past and present research of this molecule, to finally bring a perspective on what will be next in this promising field of study. Molecular Diversity Preservation International 2010-02-10 /pmc/articles/PMC6263191/ /pubmed/20335954 http://dx.doi.org/10.3390/molecules15020878 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Túnez, Isaac
Tasset, Inmaculada
Pérez-De La Cruz, Verónica
Santamaría, Abel
3-Nitropropionic Acid as a Tool to Study the Mechanisms Involved in Huntington’s Disease: Past, Present and Future
title 3-Nitropropionic Acid as a Tool to Study the Mechanisms Involved in Huntington’s Disease: Past, Present and Future
title_full 3-Nitropropionic Acid as a Tool to Study the Mechanisms Involved in Huntington’s Disease: Past, Present and Future
title_fullStr 3-Nitropropionic Acid as a Tool to Study the Mechanisms Involved in Huntington’s Disease: Past, Present and Future
title_full_unstemmed 3-Nitropropionic Acid as a Tool to Study the Mechanisms Involved in Huntington’s Disease: Past, Present and Future
title_short 3-Nitropropionic Acid as a Tool to Study the Mechanisms Involved in Huntington’s Disease: Past, Present and Future
title_sort 3-nitropropionic acid as a tool to study the mechanisms involved in huntington’s disease: past, present and future
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263191/
https://www.ncbi.nlm.nih.gov/pubmed/20335954
http://dx.doi.org/10.3390/molecules15020878
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