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Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide

INTRODUCTION: Macrocrystalline oxides of alkaline earth metals (Mg and Ca) or light metals (Al and Ti) can respond to standard warfare agents such as sulfur mustard, soman, or agent VX. In this paper, we compared the decontamination ability of sodium hydroxide (NaOH) and sodium hypochlorite (NaClO)...

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Autores principales: Štenglová Netíková, Irena R, Petruželka, Luboš, Šťastný, Martin, Štengl, Václav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263216/
https://www.ncbi.nlm.nih.gov/pubmed/30538471
http://dx.doi.org/10.2147/IJN.S159328
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author Štenglová Netíková, Irena R
Petruželka, Luboš
Šťastný, Martin
Štengl, Václav
author_facet Štenglová Netíková, Irena R
Petruželka, Luboš
Šťastný, Martin
Štengl, Václav
author_sort Štenglová Netíková, Irena R
collection PubMed
description INTRODUCTION: Macrocrystalline oxides of alkaline earth metals (Mg and Ca) or light metals (Al and Ti) can respond to standard warfare agents such as sulfur mustard, soman, or agent VX. In this paper, we compared the decontamination ability of sodium hydroxide (NaOH) and sodium hypochlorite (NaClO) for nitrogen mustards (cyclophosphamide [CP] and ifosfamide [IFOS]) with a new procedure using a destructive sorbent based on nanocrystalline and nanodispersive titanium dioxide (TiO(2)) as a new efficient and cheap material for complete decontamination of surfaces. METHODS: Titanium (IV) dioxide nanoparticles were prepared by the homogeneous hydrolysis of titanium(IV) oxysulfate (TiOSO(4)) with urea. The as-prepared TiO(2) nanoparticles were used for the fast and safe decontamination of cytostatics from the nitrogen mustard family (CP and IFOS) in water. The adsorption–degradation process of cytostatics in the presence of TiO(2) was compared with decontamination agents (0.01 M solution of sodium hydroxide and 5% solution of sodium hypochlorite). The mechanism of the decontamination process and the degradation efficiency were determined by high-performance liquid chromatography with mass spectrometry. RESULTS: It was demonstrated that a 0.01 M solution of sodium hydroxide (NaOH) decomposes CP to 3-((amino(bis(2-chloroethyl)amino)phosphoryl)oxy)propanoic acid and sodium hypochlorite formed two reaction products, namely, IFOS and 4-hydroxy-cyclophosphamide. IFOS is cytotoxic, and 4-hydroxy-cyclophosphamide is a known metabolite of CP after its partial metabolism by CYP/CYP450. IFOS degrades in the pres¬ence of NaOH to toxic IFOS mustard. Titanium(IV) dioxide nanoparticles adsorbed on its surface CP after 5 minutes and on IFOS after 10 minutes. The adsorption–degradation process of CP in water and in the presence of TiO(2) led to 4-hydroxy-cyclophosphamide and IFOS, respectively, which decayed to oxidation product 4-hydroxy-ifosfamide. CONCLUSION: Nanodispersive TiO(2) is an effective degradation agent for decontamination of surfaces from cytostatics in medical facilities.
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spelling pubmed-62632162018-12-11 Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide Štenglová Netíková, Irena R Petruželka, Luboš Šťastný, Martin Štengl, Václav Int J Nanomedicine Original Research INTRODUCTION: Macrocrystalline oxides of alkaline earth metals (Mg and Ca) or light metals (Al and Ti) can respond to standard warfare agents such as sulfur mustard, soman, or agent VX. In this paper, we compared the decontamination ability of sodium hydroxide (NaOH) and sodium hypochlorite (NaClO) for nitrogen mustards (cyclophosphamide [CP] and ifosfamide [IFOS]) with a new procedure using a destructive sorbent based on nanocrystalline and nanodispersive titanium dioxide (TiO(2)) as a new efficient and cheap material for complete decontamination of surfaces. METHODS: Titanium (IV) dioxide nanoparticles were prepared by the homogeneous hydrolysis of titanium(IV) oxysulfate (TiOSO(4)) with urea. The as-prepared TiO(2) nanoparticles were used for the fast and safe decontamination of cytostatics from the nitrogen mustard family (CP and IFOS) in water. The adsorption–degradation process of cytostatics in the presence of TiO(2) was compared with decontamination agents (0.01 M solution of sodium hydroxide and 5% solution of sodium hypochlorite). The mechanism of the decontamination process and the degradation efficiency were determined by high-performance liquid chromatography with mass spectrometry. RESULTS: It was demonstrated that a 0.01 M solution of sodium hydroxide (NaOH) decomposes CP to 3-((amino(bis(2-chloroethyl)amino)phosphoryl)oxy)propanoic acid and sodium hypochlorite formed two reaction products, namely, IFOS and 4-hydroxy-cyclophosphamide. IFOS is cytotoxic, and 4-hydroxy-cyclophosphamide is a known metabolite of CP after its partial metabolism by CYP/CYP450. IFOS degrades in the pres¬ence of NaOH to toxic IFOS mustard. Titanium(IV) dioxide nanoparticles adsorbed on its surface CP after 5 minutes and on IFOS after 10 minutes. The adsorption–degradation process of CP in water and in the presence of TiO(2) led to 4-hydroxy-cyclophosphamide and IFOS, respectively, which decayed to oxidation product 4-hydroxy-ifosfamide. CONCLUSION: Nanodispersive TiO(2) is an effective degradation agent for decontamination of surfaces from cytostatics in medical facilities. Dove Medical Press 2018-11-26 /pmc/articles/PMC6263216/ /pubmed/30538471 http://dx.doi.org/10.2147/IJN.S159328 Text en © 2018 Štenglová Netíková et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Štenglová Netíková, Irena R
Petruželka, Luboš
Šťastný, Martin
Štengl, Václav
Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide
title Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide
title_full Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide
title_fullStr Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide
title_full_unstemmed Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide
title_short Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide
title_sort safe decontamination of cytostatics from the nitrogen mustards family. part one: cyclophosphamide and ifosfamide
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263216/
https://www.ncbi.nlm.nih.gov/pubmed/30538471
http://dx.doi.org/10.2147/IJN.S159328
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