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Sub-10 nm Cu(5)FeS(4) cube for magnetic resonance imaging-guided photothermal therapy of cancer
BACKGROUND: Facile synthesis and small size theranostic agents have shown great potential for cancer diagnosis and treatment. PURPOSE: A ternary compound (Cu(5)FeS(4)), Fe doped copper sulfide, with novel magnetic properties and strong near-infrared absorption was prepared for magnetic resonance ima...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263250/ https://www.ncbi.nlm.nih.gov/pubmed/30538472 http://dx.doi.org/10.2147/IJN.S181056 |
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author | Wang, Dan Zhang, Yuwen Guo, Qi |
author_facet | Wang, Dan Zhang, Yuwen Guo, Qi |
author_sort | Wang, Dan |
collection | PubMed |
description | BACKGROUND: Facile synthesis and small size theranostic agents have shown great potential for cancer diagnosis and treatment. PURPOSE: A ternary compound (Cu(5)FeS(4)), Fe doped copper sulfide, with novel magnetic properties and strong near-infrared absorption was prepared for magnetic resonance imaging (MRI) imaging guided photothermal therapy of cancer. PATIENTS AND METHODS: Firstly, the capability of magnetic resonance imaging based on the novel magnetic properties and the photothermal performance due to the strong near-infrared absorption was investigated in vitro. Then, the magnetic resonance imaging guided photothermal therapy for 4T1 tumor-bearing mouse was carried out. RESULTS: The Cu(5)FeS(4) cube with good T(1)-weighted MRI, excellent photothermal performance and low cytotoxicity has been investigated. More importantly, the T(1)-weighted MRI for 4T1 tumor-bearing mouse will get the best contrast effect at tumor site after 8 h of intravenous injection of Cu(5)FeS(4) cube. Under the guidance of the T(1)-weighted MRI, the PTT was carried out at 8 h after intravenous injection of Cu(5)FeS(4) cube and only the group combined intravenous administration of Cu(5)FeS(4) cube and laser irradiation nearly cured the tumor after 14 days. CONCLUSION: Our study not only provides a new material for personalized treatment of tumors, but also further promotes potential applications of the cancer theranostic agents. |
format | Online Article Text |
id | pubmed-6263250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-62632502018-12-11 Sub-10 nm Cu(5)FeS(4) cube for magnetic resonance imaging-guided photothermal therapy of cancer Wang, Dan Zhang, Yuwen Guo, Qi Int J Nanomedicine Original Research BACKGROUND: Facile synthesis and small size theranostic agents have shown great potential for cancer diagnosis and treatment. PURPOSE: A ternary compound (Cu(5)FeS(4)), Fe doped copper sulfide, with novel magnetic properties and strong near-infrared absorption was prepared for magnetic resonance imaging (MRI) imaging guided photothermal therapy of cancer. PATIENTS AND METHODS: Firstly, the capability of magnetic resonance imaging based on the novel magnetic properties and the photothermal performance due to the strong near-infrared absorption was investigated in vitro. Then, the magnetic resonance imaging guided photothermal therapy for 4T1 tumor-bearing mouse was carried out. RESULTS: The Cu(5)FeS(4) cube with good T(1)-weighted MRI, excellent photothermal performance and low cytotoxicity has been investigated. More importantly, the T(1)-weighted MRI for 4T1 tumor-bearing mouse will get the best contrast effect at tumor site after 8 h of intravenous injection of Cu(5)FeS(4) cube. Under the guidance of the T(1)-weighted MRI, the PTT was carried out at 8 h after intravenous injection of Cu(5)FeS(4) cube and only the group combined intravenous administration of Cu(5)FeS(4) cube and laser irradiation nearly cured the tumor after 14 days. CONCLUSION: Our study not only provides a new material for personalized treatment of tumors, but also further promotes potential applications of the cancer theranostic agents. Dove Medical Press 2018-11-26 /pmc/articles/PMC6263250/ /pubmed/30538472 http://dx.doi.org/10.2147/IJN.S181056 Text en © 2018 Wang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed |
spellingShingle | Original Research Wang, Dan Zhang, Yuwen Guo, Qi Sub-10 nm Cu(5)FeS(4) cube for magnetic resonance imaging-guided photothermal therapy of cancer |
title | Sub-10 nm Cu(5)FeS(4) cube for magnetic resonance imaging-guided photothermal therapy of cancer |
title_full | Sub-10 nm Cu(5)FeS(4) cube for magnetic resonance imaging-guided photothermal therapy of cancer |
title_fullStr | Sub-10 nm Cu(5)FeS(4) cube for magnetic resonance imaging-guided photothermal therapy of cancer |
title_full_unstemmed | Sub-10 nm Cu(5)FeS(4) cube for magnetic resonance imaging-guided photothermal therapy of cancer |
title_short | Sub-10 nm Cu(5)FeS(4) cube for magnetic resonance imaging-guided photothermal therapy of cancer |
title_sort | sub-10 nm cu(5)fes(4) cube for magnetic resonance imaging-guided photothermal therapy of cancer |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263250/ https://www.ncbi.nlm.nih.gov/pubmed/30538472 http://dx.doi.org/10.2147/IJN.S181056 |
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