4D-QSAR: Perspectives in Drug Design

Drug design is a process driven by innovation and technological breakthroughs involving a combination of advanced experimental and computational methods. A broad variety of medicinal chemistry approaches can be used for the identification of hits, generation of leads, as well as to accelerate the op...

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Detalles Bibliográficos
Autores principales: Andrade, Carolina H., Pasqualoto, Kerly F. M., Ferreira, Elizabeth I., Hopfinger, Anton J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263259/
https://www.ncbi.nlm.nih.gov/pubmed/20657478
http://dx.doi.org/10.3390/molecules15053281
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author Andrade, Carolina H.
Pasqualoto, Kerly F. M.
Ferreira, Elizabeth I.
Hopfinger, Anton J.
author_facet Andrade, Carolina H.
Pasqualoto, Kerly F. M.
Ferreira, Elizabeth I.
Hopfinger, Anton J.
author_sort Andrade, Carolina H.
collection PubMed
description Drug design is a process driven by innovation and technological breakthroughs involving a combination of advanced experimental and computational methods. A broad variety of medicinal chemistry approaches can be used for the identification of hits, generation of leads, as well as to accelerate the optimization of leads into drug candidates. The quantitative structure–activity relationship (QSAR) formalisms are among the most important strategies that can be applied for the successful design new molecules. This review provides a comprehensive review on the evolution and current status of 4D-QSAR, highlighting present challenges and new opportunities in drug design.
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spelling pubmed-62632592019-01-02 4D-QSAR: Perspectives in Drug Design Andrade, Carolina H. Pasqualoto, Kerly F. M. Ferreira, Elizabeth I. Hopfinger, Anton J. Molecules Review Drug design is a process driven by innovation and technological breakthroughs involving a combination of advanced experimental and computational methods. A broad variety of medicinal chemistry approaches can be used for the identification of hits, generation of leads, as well as to accelerate the optimization of leads into drug candidates. The quantitative structure–activity relationship (QSAR) formalisms are among the most important strategies that can be applied for the successful design new molecules. This review provides a comprehensive review on the evolution and current status of 4D-QSAR, highlighting present challenges and new opportunities in drug design. MDPI 2010-05-04 /pmc/articles/PMC6263259/ /pubmed/20657478 http://dx.doi.org/10.3390/molecules15053281 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Andrade, Carolina H.
Pasqualoto, Kerly F. M.
Ferreira, Elizabeth I.
Hopfinger, Anton J.
4D-QSAR: Perspectives in Drug Design
title 4D-QSAR: Perspectives in Drug Design
title_full 4D-QSAR: Perspectives in Drug Design
title_fullStr 4D-QSAR: Perspectives in Drug Design
title_full_unstemmed 4D-QSAR: Perspectives in Drug Design
title_short 4D-QSAR: Perspectives in Drug Design
title_sort 4d-qsar: perspectives in drug design
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263259/
https://www.ncbi.nlm.nih.gov/pubmed/20657478
http://dx.doi.org/10.3390/molecules15053281
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