A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles

N-Methyl-3-acylpyrroles were synthesized via a multicomponent reaction of dimethylacetylene dicarboxylate (DMAD), N-methylhydroxylamine and acylchlorides in the presence of KHCO(3). For comparison both conventional and microwave protocols were examined in this procedure. The reaction is clean and gi...

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Detalles Bibliográficos
Autores principales: Valizadeh, Hassan, Fakhari, Ashraf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263317/
https://www.ncbi.nlm.nih.gov/pubmed/20657459
http://dx.doi.org/10.3390/molecules15052972
Descripción
Sumario:N-Methyl-3-acylpyrroles were synthesized via a multicomponent reaction of dimethylacetylene dicarboxylate (DMAD), N-methylhydroxylamine and acylchlorides in the presence of KHCO(3). For comparison both conventional and microwave protocols were examined in this procedure. The reaction is clean and gives the products in good to excellent yields under conventional heating conditions at 40 ºC in anhydrous dichloromethane.

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