A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles

N-Methyl-3-acylpyrroles were synthesized via a multicomponent reaction of dimethylacetylene dicarboxylate (DMAD), N-methylhydroxylamine and acylchlorides in the presence of KHCO(3). For comparison both conventional and microwave protocols were examined in this procedure. The reaction is clean and gi...

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Autores principales: Valizadeh, Hassan, Fakhari, Ashraf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263317/
https://www.ncbi.nlm.nih.gov/pubmed/20657459
http://dx.doi.org/10.3390/molecules15052972
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author Valizadeh, Hassan
Fakhari, Ashraf
author_facet Valizadeh, Hassan
Fakhari, Ashraf
author_sort Valizadeh, Hassan
collection PubMed
description N-Methyl-3-acylpyrroles were synthesized via a multicomponent reaction of dimethylacetylene dicarboxylate (DMAD), N-methylhydroxylamine and acylchlorides in the presence of KHCO(3). For comparison both conventional and microwave protocols were examined in this procedure. The reaction is clean and gives the products in good to excellent yields under conventional heating conditions at 40 ºC in anhydrous dichloromethane.
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spelling pubmed-62633172019-01-02 A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles Valizadeh, Hassan Fakhari, Ashraf Molecules Article N-Methyl-3-acylpyrroles were synthesized via a multicomponent reaction of dimethylacetylene dicarboxylate (DMAD), N-methylhydroxylamine and acylchlorides in the presence of KHCO(3). For comparison both conventional and microwave protocols were examined in this procedure. The reaction is clean and gives the products in good to excellent yields under conventional heating conditions at 40 ºC in anhydrous dichloromethane. MDPI 2010-04-27 /pmc/articles/PMC6263317/ /pubmed/20657459 http://dx.doi.org/10.3390/molecules15052972 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Valizadeh, Hassan
Fakhari, Ashraf
A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles
title A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles
title_full A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles
title_fullStr A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles
title_full_unstemmed A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles
title_short A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles
title_sort mild and facile one-pot synthesis of n-methyl-3-acyl-pyrroles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263317/
https://www.ncbi.nlm.nih.gov/pubmed/20657459
http://dx.doi.org/10.3390/molecules15052972
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