Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane

1,2-bis(2-methylallyl)disulfane was synthesized from sodium sulfide and 3-chloro-2-methylpropylene. The structure of the target product was confirmed by GC-MS, (1)H-NMR and elemental analysis. Cell viability assay, flow-cytometric analysis and protein expression results showed that 1,2-bis(2-methyla...

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Autores principales: Ji, Chunxiao, Ren, Fenglian, Dai, Jun, Xu, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263348/
https://www.ncbi.nlm.nih.gov/pubmed/20657504
http://dx.doi.org/10.3390/molecules15053634
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author Ji, Chunxiao
Ren, Fenglian
Dai, Jun
Xu, Ming
author_facet Ji, Chunxiao
Ren, Fenglian
Dai, Jun
Xu, Ming
author_sort Ji, Chunxiao
collection PubMed
description 1,2-bis(2-methylallyl)disulfane was synthesized from sodium sulfide and 3-chloro-2-methylpropylene. The structure of the target product was confirmed by GC-MS, (1)H-NMR and elemental analysis. Cell viability assay, flow-cytometric analysis and protein expression results showed that 1,2-bis(2-methylallyl)disulfane could significantly inhibit the proliferation, and induce the apoptosis of human HepG2 cells.
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spelling pubmed-62633482019-01-02 Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane Ji, Chunxiao Ren, Fenglian Dai, Jun Xu, Ming Molecules Article 1,2-bis(2-methylallyl)disulfane was synthesized from sodium sulfide and 3-chloro-2-methylpropylene. The structure of the target product was confirmed by GC-MS, (1)H-NMR and elemental analysis. Cell viability assay, flow-cytometric analysis and protein expression results showed that 1,2-bis(2-methylallyl)disulfane could significantly inhibit the proliferation, and induce the apoptosis of human HepG2 cells. MDPI 2010-05-18 /pmc/articles/PMC6263348/ /pubmed/20657504 http://dx.doi.org/10.3390/molecules15053634 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Ji, Chunxiao
Ren, Fenglian
Dai, Jun
Xu, Ming
Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane
title Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane
title_full Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane
title_fullStr Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane
title_full_unstemmed Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane
title_short Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane
title_sort synthesis and effect on human hepg2 cells of 1,2-bis- (2-methylallyl)disulfane
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263348/
https://www.ncbi.nlm.nih.gov/pubmed/20657504
http://dx.doi.org/10.3390/molecules15053634
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