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A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation
Background: Recent studies have shown that subclinical valve thrombosis in heart valve prosthesis (HVP) can be responsible for reduced leaflet motion detectable only by advanced imaging diagnostics. We conceived a novel sensorized HVP able to detect earlier any thrombus formation that may alter the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263652/ https://www.ncbi.nlm.nih.gov/pubmed/30428516 http://dx.doi.org/10.3390/s18113905 |
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author | Marcelli, Emanuela Bortolani, Barbara Corazza, Ivan Cercenelli, Laura |
author_facet | Marcelli, Emanuela Bortolani, Barbara Corazza, Ivan Cercenelli, Laura |
author_sort | Marcelli, Emanuela |
collection | PubMed |
description | Background: Recent studies have shown that subclinical valve thrombosis in heart valve prosthesis (HVP) can be responsible for reduced leaflet motion detectable only by advanced imaging diagnostics. We conceived a novel sensorized HVP able to detect earlier any thrombus formation that may alter the leaflets motion using an electric impedance measurement, IntraValvular Impedance (IVI). Methods: For IVI measurement, dedicated electrodes are embedded in the structure of the HVP to generate a local electric field that is altered by the moving valve leaflets during their cyclic opening/closing. We present preliminary in vitro results using a first prototype of sensorized mechanical heart valve connected to an external impedance measurement system. The prototype was tested on a circulatory mock loop system and the IVI signals were recorded during both normal dynamics and experimentally induced altered working of the leaflets. Results: Recordings showed a very repetitive and stable IVI signal during the normal cyclic opening/closing of the HVP. The induced alterations in leaflet motion were reflected in the IVI signal. Conclusions: The novel sensorized HVP has great potential to give early warning of possible subclinical valve thrombosis altering the valve leaflet motion, and to help in tailoring the anticoagulation therapy. |
format | Online Article Text |
id | pubmed-6263652 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62636522018-12-12 A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation Marcelli, Emanuela Bortolani, Barbara Corazza, Ivan Cercenelli, Laura Sensors (Basel) Article Background: Recent studies have shown that subclinical valve thrombosis in heart valve prosthesis (HVP) can be responsible for reduced leaflet motion detectable only by advanced imaging diagnostics. We conceived a novel sensorized HVP able to detect earlier any thrombus formation that may alter the leaflets motion using an electric impedance measurement, IntraValvular Impedance (IVI). Methods: For IVI measurement, dedicated electrodes are embedded in the structure of the HVP to generate a local electric field that is altered by the moving valve leaflets during their cyclic opening/closing. We present preliminary in vitro results using a first prototype of sensorized mechanical heart valve connected to an external impedance measurement system. The prototype was tested on a circulatory mock loop system and the IVI signals were recorded during both normal dynamics and experimentally induced altered working of the leaflets. Results: Recordings showed a very repetitive and stable IVI signal during the normal cyclic opening/closing of the HVP. The induced alterations in leaflet motion were reflected in the IVI signal. Conclusions: The novel sensorized HVP has great potential to give early warning of possible subclinical valve thrombosis altering the valve leaflet motion, and to help in tailoring the anticoagulation therapy. MDPI 2018-11-13 /pmc/articles/PMC6263652/ /pubmed/30428516 http://dx.doi.org/10.3390/s18113905 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Marcelli, Emanuela Bortolani, Barbara Corazza, Ivan Cercenelli, Laura A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation |
title | A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation |
title_full | A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation |
title_fullStr | A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation |
title_full_unstemmed | A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation |
title_short | A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation |
title_sort | novel sensorized heart valve prosthesis: preliminary in vitro evaluation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263652/ https://www.ncbi.nlm.nih.gov/pubmed/30428516 http://dx.doi.org/10.3390/s18113905 |
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