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A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation

Background: Recent studies have shown that subclinical valve thrombosis in heart valve prosthesis (HVP) can be responsible for reduced leaflet motion detectable only by advanced imaging diagnostics. We conceived a novel sensorized HVP able to detect earlier any thrombus formation that may alter the...

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Autores principales: Marcelli, Emanuela, Bortolani, Barbara, Corazza, Ivan, Cercenelli, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263652/
https://www.ncbi.nlm.nih.gov/pubmed/30428516
http://dx.doi.org/10.3390/s18113905
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author Marcelli, Emanuela
Bortolani, Barbara
Corazza, Ivan
Cercenelli, Laura
author_facet Marcelli, Emanuela
Bortolani, Barbara
Corazza, Ivan
Cercenelli, Laura
author_sort Marcelli, Emanuela
collection PubMed
description Background: Recent studies have shown that subclinical valve thrombosis in heart valve prosthesis (HVP) can be responsible for reduced leaflet motion detectable only by advanced imaging diagnostics. We conceived a novel sensorized HVP able to detect earlier any thrombus formation that may alter the leaflets motion using an electric impedance measurement, IntraValvular Impedance (IVI). Methods: For IVI measurement, dedicated electrodes are embedded in the structure of the HVP to generate a local electric field that is altered by the moving valve leaflets during their cyclic opening/closing. We present preliminary in vitro results using a first prototype of sensorized mechanical heart valve connected to an external impedance measurement system. The prototype was tested on a circulatory mock loop system and the IVI signals were recorded during both normal dynamics and experimentally induced altered working of the leaflets. Results: Recordings showed a very repetitive and stable IVI signal during the normal cyclic opening/closing of the HVP. The induced alterations in leaflet motion were reflected in the IVI signal. Conclusions: The novel sensorized HVP has great potential to give early warning of possible subclinical valve thrombosis altering the valve leaflet motion, and to help in tailoring the anticoagulation therapy.
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spelling pubmed-62636522018-12-12 A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation Marcelli, Emanuela Bortolani, Barbara Corazza, Ivan Cercenelli, Laura Sensors (Basel) Article Background: Recent studies have shown that subclinical valve thrombosis in heart valve prosthesis (HVP) can be responsible for reduced leaflet motion detectable only by advanced imaging diagnostics. We conceived a novel sensorized HVP able to detect earlier any thrombus formation that may alter the leaflets motion using an electric impedance measurement, IntraValvular Impedance (IVI). Methods: For IVI measurement, dedicated electrodes are embedded in the structure of the HVP to generate a local electric field that is altered by the moving valve leaflets during their cyclic opening/closing. We present preliminary in vitro results using a first prototype of sensorized mechanical heart valve connected to an external impedance measurement system. The prototype was tested on a circulatory mock loop system and the IVI signals were recorded during both normal dynamics and experimentally induced altered working of the leaflets. Results: Recordings showed a very repetitive and stable IVI signal during the normal cyclic opening/closing of the HVP. The induced alterations in leaflet motion were reflected in the IVI signal. Conclusions: The novel sensorized HVP has great potential to give early warning of possible subclinical valve thrombosis altering the valve leaflet motion, and to help in tailoring the anticoagulation therapy. MDPI 2018-11-13 /pmc/articles/PMC6263652/ /pubmed/30428516 http://dx.doi.org/10.3390/s18113905 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Marcelli, Emanuela
Bortolani, Barbara
Corazza, Ivan
Cercenelli, Laura
A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation
title A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation
title_full A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation
title_fullStr A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation
title_full_unstemmed A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation
title_short A Novel Sensorized Heart Valve Prosthesis: Preliminary In Vitro Evaluation
title_sort novel sensorized heart valve prosthesis: preliminary in vitro evaluation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263652/
https://www.ncbi.nlm.nih.gov/pubmed/30428516
http://dx.doi.org/10.3390/s18113905
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