Establishing a Multidisciplinary Framework to Study Drug‐Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate

Hormonal contraceptive agents (HCAs) are widely used throughout the world, and women taking HCAs are likely to take other medications. However, little is known about the clinical effect of most drug‐drug interactions (DDIs) associated with HCAs. A team of interdisciplinary outcomes and pharmacometri...

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Detalles Bibliográficos
Autores principales: Lesko, Lawrence J., Vozmediano, Valvanera, Brown, Joshua D., Winterstein, Almut, Zhao, Ping, Lippert, Jörg, Höchel, Joachim, Chaturvedula, Ayyappa, White, Annesha, Schmidt, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263668/
https://www.ncbi.nlm.nih.gov/pubmed/30260082
http://dx.doi.org/10.1002/psp4.12357
Descripción
Sumario:Hormonal contraceptive agents (HCAs) are widely used throughout the world, and women taking HCAs are likely to take other medications. However, little is known about the clinical effect of most drug‐drug interactions (DDIs) associated with HCAs. A team of interdisciplinary outcomes and pharmacometric researchers from academia and industry jointly engage in a research project to (i) quantitatively elucidate DDI impacts on unintended pregnancies and breakthrough bleeding, and (ii) establish a DDI‐prediction framework to inform optimal use of HCAs.

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