Metabolic control of PPAR activity by aldehyde dehydrogenase regulates invasive cell behavior and predicts survival in hepatocellular and renal clear cell carcinoma

BACKGROUND: Changes in cellular metabolism are now recognized as potential drivers of cancer development, rather than as secondary consequences of disease. Here, we explore the mechanism by which metabolic changes dependent on aldehyde dehydrogenase impact cancer development. METHODS: ALDH7A1 was id...

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Detalles Bibliográficos
Autores principales: Andrejeva, Diana, Kugler, Jan-Michael, Nguyen, Hung Thanh, Malmendal, Anders, Holm, Mette Lind, Toft, Birgitte Groenkaer, Loya, Anand C., Cohen, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264057/
https://www.ncbi.nlm.nih.gov/pubmed/30486822
http://dx.doi.org/10.1186/s12885-018-5061-7

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