Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes

A rational approach was used to synthesize a new set of 15 1H-1,2,4-triazol-3-yl benzenesulfonamide derivatives with the aim of developing new antimalarial lead compounds. These derivatives were prepared in yields between 50% and 62%, and their structures were elucidated using IR, (1)H-, (13)C-, (19...

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Autores principales: Boechat, Nubia, Pinheiro, Luiz C.S., Santos-Filho, Osvaldo A., Silva, Isabor C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264137/
https://www.ncbi.nlm.nih.gov/pubmed/21934646
http://dx.doi.org/10.3390/molecules16098083
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author Boechat, Nubia
Pinheiro, Luiz C.S.
Santos-Filho, Osvaldo A.
Silva, Isabor C.
author_facet Boechat, Nubia
Pinheiro, Luiz C.S.
Santos-Filho, Osvaldo A.
Silva, Isabor C.
author_sort Boechat, Nubia
collection PubMed
description A rational approach was used to synthesize a new set of 15 1H-1,2,4-triazol-3-yl benzenesulfonamide derivatives with the aim of developing new antimalarial lead compounds. These derivatives were prepared in yields between 50% and 62%, and their structures were elucidated using IR, (1)H-, (13)C-, (19)F-NMR, MS and elemental analysis. A docking study based on sulfonamides previously used against malaria identified trifluoromethyl-substituted derivatives to be the best lead compounds for new antimalarial drug development.
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spelling pubmed-62641372018-12-10 Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes Boechat, Nubia Pinheiro, Luiz C.S. Santos-Filho, Osvaldo A. Silva, Isabor C. Molecules Article A rational approach was used to synthesize a new set of 15 1H-1,2,4-triazol-3-yl benzenesulfonamide derivatives with the aim of developing new antimalarial lead compounds. These derivatives were prepared in yields between 50% and 62%, and their structures were elucidated using IR, (1)H-, (13)C-, (19)F-NMR, MS and elemental analysis. A docking study based on sulfonamides previously used against malaria identified trifluoromethyl-substituted derivatives to be the best lead compounds for new antimalarial drug development. MDPI 2011-09-20 /pmc/articles/PMC6264137/ /pubmed/21934646 http://dx.doi.org/10.3390/molecules16098083 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Boechat, Nubia
Pinheiro, Luiz C.S.
Santos-Filho, Osvaldo A.
Silva, Isabor C.
Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes
title Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes
title_full Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes
title_fullStr Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes
title_full_unstemmed Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes
title_short Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes
title_sort design and synthesis of new n-(5-trifluoromethyl)-1h-1,2,4-triazol-3-yl benzenesulfonamides as possible antimalarial prototypes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264137/
https://www.ncbi.nlm.nih.gov/pubmed/21934646
http://dx.doi.org/10.3390/molecules16098083
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