Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier

Transmissible spongiform encephalopathies (TSEs) are caused by the prion, which consists essentially of PrP(Sc), an aggregated, conformationally modified form of the cellular prion protein (PrP(C)). Although TSEs can be experimentally transmitted by intracerebral inoculation, most instances of infec...

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Detalles Bibliográficos
Autores principales: Keller, Annika, Nuvolone, Mario, Abakumova, Irina, Chincisan, Andra, Reimann, Regina, Avar, Merve, Heinzer, Daniel, Hornemann, Simone, Wagner, Josephin, Kirschenbaum, Daniel, Voigt, Fabian F., Zhu, Caihong, Regli, Luca, Helmchen, Fritjof, Aguzzi, Adriano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264140/
https://www.ncbi.nlm.nih.gov/pubmed/30496289
http://dx.doi.org/10.1371/journal.ppat.1007424

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