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Hepatoprotective Action of Radix Paeoniae Rubra Aqueous Extract against CCl(4)-Induced Hepatic Damage

In the present study the capacity of Radix Paeoniae Rubra aqueous extract (RPRAE) as an antioxidant to protect against carbon tetrachloride (CCl(4))-induced oxidative stress and hepatotoxicity in Wistar rats was investigated. Six groups of rats were used. Radix Paeoniae Rubra aqueous extract (100 or...

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Autores principales: Li, Ruidong, Guo, Wenyuan, Fu, Zhiren, Ding, Guoshan, Zou, You, Wang, Zhengxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264168/
https://www.ncbi.nlm.nih.gov/pubmed/22005833
http://dx.doi.org/10.3390/molecules16108684
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author Li, Ruidong
Guo, Wenyuan
Fu, Zhiren
Ding, Guoshan
Zou, You
Wang, Zhengxin
author_facet Li, Ruidong
Guo, Wenyuan
Fu, Zhiren
Ding, Guoshan
Zou, You
Wang, Zhengxin
author_sort Li, Ruidong
collection PubMed
description In the present study the capacity of Radix Paeoniae Rubra aqueous extract (RPRAE) as an antioxidant to protect against carbon tetrachloride (CCl(4))-induced oxidative stress and hepatotoxicity in Wistar rats was investigated. Six groups of rats were used. Radix Paeoniae Rubra aqueous extract (100 or 200 or 300 mg/kg of bw) or bifendate (100 mg/kg of bw) were given daily by gavage to the animals on 28 consecutive days to elucidate the protective effects against CCl(4)-induced hepatotoxicity. The 20% CCl(4)/olive oil was gavage of gastric tube twice a week (on the third and seventh days of each week). The animals of normal control group were given only vehicle. The animals of CCl(4)-treated group were administered with CCl(4) twice a week (on the third and seventh days of each week) and with vehicle on rest of the days. The test materials were found effective as hepatoprotective agents, as evidenced by plasma and liver biochemical parameters. Therefore, the results of this study show that Radix Paeoniae Rubra aqueous extract can protect the liver against CCl(4)-induced oxidative damage in rats, and the hepatoprotective effects might be correlated with its antioxidant and free radical scavenger effects.
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spelling pubmed-62641682018-12-10 Hepatoprotective Action of Radix Paeoniae Rubra Aqueous Extract against CCl(4)-Induced Hepatic Damage Li, Ruidong Guo, Wenyuan Fu, Zhiren Ding, Guoshan Zou, You Wang, Zhengxin Molecules Article In the present study the capacity of Radix Paeoniae Rubra aqueous extract (RPRAE) as an antioxidant to protect against carbon tetrachloride (CCl(4))-induced oxidative stress and hepatotoxicity in Wistar rats was investigated. Six groups of rats were used. Radix Paeoniae Rubra aqueous extract (100 or 200 or 300 mg/kg of bw) or bifendate (100 mg/kg of bw) were given daily by gavage to the animals on 28 consecutive days to elucidate the protective effects against CCl(4)-induced hepatotoxicity. The 20% CCl(4)/olive oil was gavage of gastric tube twice a week (on the third and seventh days of each week). The animals of normal control group were given only vehicle. The animals of CCl(4)-treated group were administered with CCl(4) twice a week (on the third and seventh days of each week) and with vehicle on rest of the days. The test materials were found effective as hepatoprotective agents, as evidenced by plasma and liver biochemical parameters. Therefore, the results of this study show that Radix Paeoniae Rubra aqueous extract can protect the liver against CCl(4)-induced oxidative damage in rats, and the hepatoprotective effects might be correlated with its antioxidant and free radical scavenger effects. MDPI 2011-10-17 /pmc/articles/PMC6264168/ /pubmed/22005833 http://dx.doi.org/10.3390/molecules16108684 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Li, Ruidong
Guo, Wenyuan
Fu, Zhiren
Ding, Guoshan
Zou, You
Wang, Zhengxin
Hepatoprotective Action of Radix Paeoniae Rubra Aqueous Extract against CCl(4)-Induced Hepatic Damage
title Hepatoprotective Action of Radix Paeoniae Rubra Aqueous Extract against CCl(4)-Induced Hepatic Damage
title_full Hepatoprotective Action of Radix Paeoniae Rubra Aqueous Extract against CCl(4)-Induced Hepatic Damage
title_fullStr Hepatoprotective Action of Radix Paeoniae Rubra Aqueous Extract against CCl(4)-Induced Hepatic Damage
title_full_unstemmed Hepatoprotective Action of Radix Paeoniae Rubra Aqueous Extract against CCl(4)-Induced Hepatic Damage
title_short Hepatoprotective Action of Radix Paeoniae Rubra Aqueous Extract against CCl(4)-Induced Hepatic Damage
title_sort hepatoprotective action of radix paeoniae rubra aqueous extract against ccl(4)-induced hepatic damage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264168/
https://www.ncbi.nlm.nih.gov/pubmed/22005833
http://dx.doi.org/10.3390/molecules16108684
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