Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba

The ethyl acetate soluble fraction from the roots of Sanguisorba tenuifolia was found to have a hypoglucemic effect in alloxan-induced diabetic rats. Two new triterpenoids, identified as 2-oxo-3β,19α-dihydroxyolean-12-en-28-oic acid β-D-gluco-pyranosyl ester (1) and 2α,19α-dihydroxy-3-oxo-12-ursen-2...

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Detalles Bibliográficos
Autores principales: Kuang, Hai-Xue, Li, Hong-Wei, Wang, Qiu-Hong, Yang, Bing-You, Wang, Zhi-Bin, Xia, Yong-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264179/
https://www.ncbi.nlm.nih.gov/pubmed/21642938
http://dx.doi.org/10.3390/molecules16064642
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author Kuang, Hai-Xue
Li, Hong-Wei
Wang, Qiu-Hong
Yang, Bing-You
Wang, Zhi-Bin
Xia, Yong-Gang
author_facet Kuang, Hai-Xue
Li, Hong-Wei
Wang, Qiu-Hong
Yang, Bing-You
Wang, Zhi-Bin
Xia, Yong-Gang
author_sort Kuang, Hai-Xue
collection PubMed
description The ethyl acetate soluble fraction from the roots of Sanguisorba tenuifolia was found to have a hypoglucemic effect in alloxan-induced diabetic rats. Two new triterpenoids, identified as 2-oxo-3β,19α-dihydroxyolean-12-en-28-oic acid β-D-gluco-pyranosyl ester (1) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid β-D-glucopyranosyl ester (4) were isolated from this fraction, along with thirteen known triterpenoids. Their structures were elucidated by chemical and spectroscopic methods. All these compounds demonstrated inhibitory activities against α-glucosidase with IC(50) values in the 0.62-3.62 mM range.
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spelling pubmed-62641792018-12-10 Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba Kuang, Hai-Xue Li, Hong-Wei Wang, Qiu-Hong Yang, Bing-You Wang, Zhi-Bin Xia, Yong-Gang Molecules Article The ethyl acetate soluble fraction from the roots of Sanguisorba tenuifolia was found to have a hypoglucemic effect in alloxan-induced diabetic rats. Two new triterpenoids, identified as 2-oxo-3β,19α-dihydroxyolean-12-en-28-oic acid β-D-gluco-pyranosyl ester (1) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid β-D-glucopyranosyl ester (4) were isolated from this fraction, along with thirteen known triterpenoids. Their structures were elucidated by chemical and spectroscopic methods. All these compounds demonstrated inhibitory activities against α-glucosidase with IC(50) values in the 0.62-3.62 mM range. MDPI 2011-06-03 /pmc/articles/PMC6264179/ /pubmed/21642938 http://dx.doi.org/10.3390/molecules16064642 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Kuang, Hai-Xue
Li, Hong-Wei
Wang, Qiu-Hong
Yang, Bing-You
Wang, Zhi-Bin
Xia, Yong-Gang
Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba
title Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba
title_full Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba
title_fullStr Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba
title_full_unstemmed Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba
title_short Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba
title_sort triterpenoids from the roots of sanguisorba tenuifolia var. alba
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264179/
https://www.ncbi.nlm.nih.gov/pubmed/21642938
http://dx.doi.org/10.3390/molecules16064642
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