Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly

We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self-assemble into long duplexes through a sticky-end approach. Addition of weakly binding...

Descripción completa

Detalles Bibliográficos
Autores principales: Burns, Jonathan R., Zekonyte, Jurgita, Siligardi, Giuliano, Hussain, Rohanah, Stulz, Eugen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264196/
https://www.ncbi.nlm.nih.gov/pubmed/21677604
http://dx.doi.org/10.3390/molecules16064912
_version_ 1783375441018486784
author Burns, Jonathan R.
Zekonyte, Jurgita
Siligardi, Giuliano
Hussain, Rohanah
Stulz, Eugen
author_facet Burns, Jonathan R.
Zekonyte, Jurgita
Siligardi, Giuliano
Hussain, Rohanah
Stulz, Eugen
author_sort Burns, Jonathan R.
collection PubMed
description We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self-assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II) and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers.
format Online
Article
Text
id pubmed-6264196
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62641962018-12-10 Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly Burns, Jonathan R. Zekonyte, Jurgita Siligardi, Giuliano Hussain, Rohanah Stulz, Eugen Molecules Communication We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self-assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II) and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers. MDPI 2011-06-15 /pmc/articles/PMC6264196/ /pubmed/21677604 http://dx.doi.org/10.3390/molecules16064912 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Burns, Jonathan R.
Zekonyte, Jurgita
Siligardi, Giuliano
Hussain, Rohanah
Stulz, Eugen
Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly
title Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly
title_full Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly
title_fullStr Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly
title_full_unstemmed Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly
title_short Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly
title_sort directed formation of dna nanoarrays through orthogonal self-assembly
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264196/
https://www.ncbi.nlm.nih.gov/pubmed/21677604
http://dx.doi.org/10.3390/molecules16064912
work_keys_str_mv AT burnsjonathanr directedformationofdnananoarraysthroughorthogonalselfassembly
AT zekonytejurgita directedformationofdnananoarraysthroughorthogonalselfassembly
AT siligardigiuliano directedformationofdnananoarraysthroughorthogonalselfassembly
AT hussainrohanah directedformationofdnananoarraysthroughorthogonalselfassembly
AT stulzeugen directedformationofdnananoarraysthroughorthogonalselfassembly

Ejemplares similares