High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach

We report herein the synthesis of substituted 2--[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-1-arylethanols, ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)-phenyl]-2-hydroxypropanoate and 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)benzyl]-2-hydroxy-acenaphthylen-1(2H)-one from the reactio...

Descripción completa

Detalles Bibliográficos
Autores principales: Juspin, Thierry, Zink, Laura, Crozet, Maxime D., Terme, Thierry, Vanelle, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264209/
https://www.ncbi.nlm.nih.gov/pubmed/21841727
http://dx.doi.org/10.3390/molecules16086883
_version_ 1783375444052017152
author Juspin, Thierry
Zink, Laura
Crozet, Maxime D.
Terme, Thierry
Vanelle, Patrice
author_facet Juspin, Thierry
Zink, Laura
Crozet, Maxime D.
Terme, Thierry
Vanelle, Patrice
author_sort Juspin, Thierry
collection PubMed
description We report herein the synthesis of substituted 2--[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-1-arylethanols, ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)-phenyl]-2-hydroxypropanoate and 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)benzyl]-2-hydroxy-acenaphthylen-1(2H)-one from the reactions of 4-[4-(chloromethyl)phenyl]-1,2-dimethyl-5-nitro-1H-imidazole with various aromatic carbonyl and α-carbonyl ester derivatives using tetrakis(dimethylamino)ethylene (TDAE) methodology.
format Online
Article
Text
id pubmed-6264209
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62642092018-12-10 High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach Juspin, Thierry Zink, Laura Crozet, Maxime D. Terme, Thierry Vanelle, Patrice Molecules Communication We report herein the synthesis of substituted 2--[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-1-arylethanols, ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)-phenyl]-2-hydroxypropanoate and 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)benzyl]-2-hydroxy-acenaphthylen-1(2H)-one from the reactions of 4-[4-(chloromethyl)phenyl]-1,2-dimethyl-5-nitro-1H-imidazole with various aromatic carbonyl and α-carbonyl ester derivatives using tetrakis(dimethylamino)ethylene (TDAE) methodology. MDPI 2011-08-12 /pmc/articles/PMC6264209/ /pubmed/21841727 http://dx.doi.org/10.3390/molecules16086883 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Juspin, Thierry
Zink, Laura
Crozet, Maxime D.
Terme, Thierry
Vanelle, Patrice
High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach
title High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach
title_full High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach
title_fullStr High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach
title_full_unstemmed High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach
title_short High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach
title_sort high functionalization of 5-nitro-1h-imidazole derivatives: the tdae approach
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264209/
https://www.ncbi.nlm.nih.gov/pubmed/21841727
http://dx.doi.org/10.3390/molecules16086883
work_keys_str_mv AT juspinthierry highfunctionalizationof5nitro1himidazolederivativesthetdaeapproach
AT zinklaura highfunctionalizationof5nitro1himidazolederivativesthetdaeapproach
AT crozetmaximed highfunctionalizationof5nitro1himidazolederivativesthetdaeapproach
AT termethierry highfunctionalizationof5nitro1himidazolederivativesthetdaeapproach
AT vanellepatrice highfunctionalizationof5nitro1himidazolederivativesthetdaeapproach

Ejemplares similares