A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives

A practical protocol for the preparation of (5Z)-2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives is reported. The new compounds were obtained in good yield and stereoselectivity in two steps, namely a solvent-free Knoevenagel condensation under microwave irradiation, f...

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Detalles Bibliográficos
Autores principales: Bourahla, Khadidja, Paquin, Ludovic, Lozach, Olivier, Meijer, Laurent, Carreaux, François, Bazureau, Jean Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264224/
https://www.ncbi.nlm.nih.gov/pubmed/21878858
http://dx.doi.org/10.3390/molecules16097377
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author Bourahla, Khadidja
Paquin, Ludovic
Lozach, Olivier
Meijer, Laurent
Carreaux, François
Bazureau, Jean Pierre
author_facet Bourahla, Khadidja
Paquin, Ludovic
Lozach, Olivier
Meijer, Laurent
Carreaux, François
Bazureau, Jean Pierre
author_sort Bourahla, Khadidja
collection PubMed
description A practical protocol for the preparation of (5Z)-2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives is reported. The new compounds were obtained in good yield and stereoselectivity in two steps, namely a solvent-free Knoevenagel condensation under microwave irradiation, followed by an S-alkylation reaction with various halogenoalkanes.
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spelling pubmed-62642242018-12-10 A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives Bourahla, Khadidja Paquin, Ludovic Lozach, Olivier Meijer, Laurent Carreaux, François Bazureau, Jean Pierre Molecules Article A practical protocol for the preparation of (5Z)-2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives is reported. The new compounds were obtained in good yield and stereoselectivity in two steps, namely a solvent-free Knoevenagel condensation under microwave irradiation, followed by an S-alkylation reaction with various halogenoalkanes. MDPI 2011-08-30 /pmc/articles/PMC6264224/ /pubmed/21878858 http://dx.doi.org/10.3390/molecules16097377 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Bourahla, Khadidja
Paquin, Ludovic
Lozach, Olivier
Meijer, Laurent
Carreaux, François
Bazureau, Jean Pierre
A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives
title A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives
title_full A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives
title_fullStr A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives
title_full_unstemmed A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives
title_short A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives
title_sort practical approach to new (5z) 2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4h-imidazol-4-one derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264224/
https://www.ncbi.nlm.nih.gov/pubmed/21878858
http://dx.doi.org/10.3390/molecules16097377
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