Cleavage of Oligonucleotides Containing a P3’→N5’ Phosphoramidate Linkage Mediated by Single-Stranded Oligonucleotide Templates

Double-stranded DNA (dsDNA) templates can hybridize to and accelerate cleavage of oligonucleotides containing a P3’→N5’ phosphoramidate (P-N) linkage. This dsDNA-templated cleavage of P-N linkages could be due to conformational strain placed on the linkage upon triplex formation. To determine whethe...

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Detalles Bibliográficos
Autores principales: Ito, Kosuke Ramon, Kodama, Tetsuya, Makimura, Futaba, Hosoki, Noritsugu, Osaki, Tomohisa, Orita, Ayako, Imanishi, Takeshi, Obika, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264227/
https://www.ncbi.nlm.nih.gov/pubmed/22186956
http://dx.doi.org/10.3390/molecules161210695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264227/
https://www.ncbi.nlm.nih.gov/pubmed/22186956
http://dx.doi.org/10.3390/molecules161210695

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