Cargando…

Cleavage of Oligonucleotides Containing a P3’→N5’ Phosphoramidate Linkage Mediated by Single-Stranded Oligonucleotide Templates

Double-stranded DNA (dsDNA) templates can hybridize to and accelerate cleavage of oligonucleotides containing a P3’→N5’ phosphoramidate (P-N) linkage. This dsDNA-templated cleavage of P-N linkages could be due to conformational strain placed on the linkage upon triplex formation. To determine whethe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ito, Kosuke Ramon, Kodama, Tetsuya, Makimura, Futaba, Hosoki, Noritsugu, Osaki, Tomohisa, Orita, Ayako, Imanishi, Takeshi, Obika, Satoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264227/ https://www.ncbi.nlm.nih.gov/pubmed/22186956 http://dx.doi.org/10.3390/molecules161210695

Ejemplares similares

Double-stranded DNA-templated cleavage of oligonucleotides containing a P3′→N5′ linkage triggered by triplex formation: the effects of chemical modifications and remarkable enhancement in reactivity
por: Ito, Kosuke Ramon, et al.
Publicado: (2010)

Solid-Phase Synthesis of Phosphorothioate/Phosphonothioate and Phosphoramidate/Phosphonamidate Oligonucleotides
por: Kostov, Ondřej, et al.
Publicado: (2019)

Synthesis of Oligonucleotides Carrying Inter-nucleotide N-(Benzoazole)-phosphoramide Moieties
por: Vasilyeva, Svetlana V., et al.
Publicado: (2022)

Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties
por: Miroshnichenko, S. K., et al.
Publicado: (2019)

Reduction of Off-Target Effects of Gapmer Antisense Oligonucleotides by Oligonucleotide Extension
por: Yasuhara, Hidenori, et al.
Publicado: (2022)

Conjugation of oligonucleotides with activated carbamate reagents prepared by the Ugi reaction for oligonucleotide library synthesis
por: Kita, Ryosuke, et al.
Publicado: (2022)

Oligonucleotide analogues with cationic backbone linkages
por: Meng, Melissa, et al.
Publicado: (2018)

A bridged nucleic acid, 2′,4′-BNA(COC): synthesis of fully modified oligonucleotides bearing thymine, 5-methylcytosine, adenine and guanine 2′,4′-BNA(COC) monomers and RNA-selective nucleic-acid recognition
por: Mitsuoka, Yasunori, et al.
Publicado: (2009)

AAV Recombineering with Single Strand Oligonucleotides
por: Hirsch, Matthew L., et al.
Publicado: (2009)

Rapid oligonucleotide-templated fluorogenic tetrazine ligations
por: Šečkutė, Jolita, et al.
Publicado: (2013)

Oligonucleotide-Templated Reactions for Sensing Nucleic Acids
por: Shibata, Aya, et al.
Publicado: (2012)

The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2′-O-Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs
por: Zhang, Lingdi, et al.
Publicado: (2022)

Modified internucleoside linkages for nuclease-resistant oligonucleotides
por: Clavé, Guillaume, et al.
Publicado: (2020)

The Position of DNA Cleavage by TALENs and Cell Synchronization Influences the Frequency of Gene Editing Directed by Single-Stranded Oligonucleotides
por: Rivera-Torres, Natalia, et al.
Publicado: (2014)

Efficient Gene Suppression by DNA/DNA Double-Stranded Oligonucleotide In Vivo
por: Asami, Yutaro, et al.
Publicado: (2021)

Chimeric oligonucleotides combining guide RNA and single-stranded DNA repair template effectively induce precision gene editing
por: Ghosh, Avantika, et al.
Publicado: (2022)

Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages
por: Liang, Xue-hai, et al.
Publicado: (2015)

Reduction of gene repair by selenomethionine with the use of single-stranded oligonucleotides
por: Schwartz, Timothy R, et al.
Publicado: (2007)

The involvement of replication in single stranded oligonucleotide-mediated gene repair
por: Huen, Michael S. Y., et al.
Publicado: (2006)

Triplex-forming oligonucleotides: a third strand for DNA nanotechnology
por: Chandrasekaran, Arun Richard, et al.
Publicado: (2018)

Guidelines for Experiments Using Antisense Oligonucleotides and Double-Stranded RNAs
por: Gagnon, Keith T., et al.
Publicado: (2019)

Enzyme-free synthesis of cyclic single-stranded DNA constructs containing a single triazole, amide or phosphoramidate backbone linkage and their use as templates for rolling circle amplification and nanoflower formation
por: Chen, Jinfeng, et al.
Publicado: (2018)

Highly efficient silencing of microRNA by heteroduplex oligonucleotides
por: Yoshioka, Kotaro, et al.
Publicado: (2019)

Strand bias influences the mechanism of gene editing directed by single-stranded DNA oligonucleotides
por: Falgowski, Kerry, et al.
Publicado: (2011)

Glucose Sensor Using Redox Active Oligonucleotide-Templated Silver Nanoclusters
por: Schroeder, Kathryn L., et al.
Publicado: (2019)

Ca(2+) enrichment in culture medium potentiates effect of oligonucleotides
por: Hori, Shin-ichiro, et al.
Publicado: (2015)

Impact of guanidine-containing backbone linkages on stereopure antisense oligonucleotides in the CNS
por: Kandasamy, Pachamuthu, et al.
Publicado: (2022)

Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes
por: Koller, Erich, et al.
Publicado: (2011)

RecA-independent single-stranded DNA oligonucleotide-mediated mutagenesis
por: Murphy, Kenan C, et al.
Publicado: (2010)

Methods for the Preparation of Large Quantities of Complex Single-Stranded Oligonucleotide Libraries
por: Murgha, Yusuf E., et al.
Publicado: (2014)

Scalable amplification of strand subsets from chip-synthesized oligonucleotide libraries
por: Schmidt, Thorsten L., et al.
Publicado: (2015)

Natural polyphenol assisted delivery of single-strand oligonucleotides by cationic polymers
por: Shen, Wanwan, et al.
Publicado: (2020)

Synthetic double-stranded RNA oligonucleotides are immunostimulatory for chicken spleen cells
por: Villanueva, A.I., et al.
Publicado: (2011)

Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection
por: Pålsson, Sandra Axberg, et al.
Publicado: (2020)

Comparative Study of Single-stranded Oligonucleotides Secondary Structure Prediction Tools
por: Binet, Thomas, et al.
Publicado: (2023)

Generation of non-genomic oligonucleotide tag sequences for RNA template-specific PCR
por: Pinto, Fernando Lopes, et al.
Publicado: (2006)

Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer–Template Complexes
por: Tam, Chun Pong, et al.
Publicado: (2017)

Superior Silencing by 2′,4′-BNA(NC)-Based Short Antisense Oligonucleotides Compared to 2′,4′-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors
por: Yamamoto, Tsuyoshi, et al.
Publicado: (2012)

Identification of nucleobase chemical modifications that reduce the hepatotoxicity of gapmer antisense oligonucleotides
por: Yoshida, Tokuyuki, et al.
Publicado: (2022)

Poly(oligonucleotide)
por: James, Carrie R., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_68cbikr98i3rmd853r70um00do