Cargando…
Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives
Twenty novel cinnamamide derivatives were designed and synthesized using as lead compound pyrimorph, whose morpholine moiety was replaced by β-phenylethylamine. All the compounds were characterized by their spectroscopic data. The fungicidal and insecticidal activities were also evaluated. The preli...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264240/ https://www.ncbi.nlm.nih.gov/pubmed/22027951 http://dx.doi.org/10.3390/molecules16118945 |
_version_ | 1783375451254685696 |
---|---|
author | Xiao, Yumei Yang, Xiaoli Li, Bo Yuan, Huizhu Wan, Shuqing Xu, Yanjun Qin, Zhaohai |
author_facet | Xiao, Yumei Yang, Xiaoli Li, Bo Yuan, Huizhu Wan, Shuqing Xu, Yanjun Qin, Zhaohai |
author_sort | Xiao, Yumei |
collection | PubMed |
description | Twenty novel cinnamamide derivatives were designed and synthesized using as lead compound pyrimorph, whose morpholine moiety was replaced by β-phenylethylamine. All the compounds were characterized by their spectroscopic data. The fungicidal and insecticidal activities were also evaluated. The preliminary results showed that all the title compounds had certain fungicidal activities against seven plant pathogens at a concentration of 50 μg/mL, and compounds 11a and 11l showed inhibition ratios of up to 90% against R. solani. Most of the title compounds exhibited moderate nematicidal activities. In general, the morpholine ring may be replaced by other amines and a chlorine atom in the pyridine ring is helpful to fungicidal activity. |
format | Online Article Text |
id | pubmed-6264240 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62642402018-12-10 Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives Xiao, Yumei Yang, Xiaoli Li, Bo Yuan, Huizhu Wan, Shuqing Xu, Yanjun Qin, Zhaohai Molecules Article Twenty novel cinnamamide derivatives were designed and synthesized using as lead compound pyrimorph, whose morpholine moiety was replaced by β-phenylethylamine. All the compounds were characterized by their spectroscopic data. The fungicidal and insecticidal activities were also evaluated. The preliminary results showed that all the title compounds had certain fungicidal activities against seven plant pathogens at a concentration of 50 μg/mL, and compounds 11a and 11l showed inhibition ratios of up to 90% against R. solani. Most of the title compounds exhibited moderate nematicidal activities. In general, the morpholine ring may be replaced by other amines and a chlorine atom in the pyridine ring is helpful to fungicidal activity. MDPI 2011-10-25 /pmc/articles/PMC6264240/ /pubmed/22027951 http://dx.doi.org/10.3390/molecules16118945 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Xiao, Yumei Yang, Xiaoli Li, Bo Yuan, Huizhu Wan, Shuqing Xu, Yanjun Qin, Zhaohai Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives |
title | Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives |
title_full | Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives |
title_fullStr | Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives |
title_full_unstemmed | Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives |
title_short | Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives |
title_sort | design, synthesis and antifungal/insecticidal evaluation of novel cinnamide derivatives |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264240/ https://www.ncbi.nlm.nih.gov/pubmed/22027951 http://dx.doi.org/10.3390/molecules16118945 |
work_keys_str_mv | AT xiaoyumei designsynthesisandantifungalinsecticidalevaluationofnovelcinnamidederivatives AT yangxiaoli designsynthesisandantifungalinsecticidalevaluationofnovelcinnamidederivatives AT libo designsynthesisandantifungalinsecticidalevaluationofnovelcinnamidederivatives AT yuanhuizhu designsynthesisandantifungalinsecticidalevaluationofnovelcinnamidederivatives AT wanshuqing designsynthesisandantifungalinsecticidalevaluationofnovelcinnamidederivatives AT xuyanjun designsynthesisandantifungalinsecticidalevaluationofnovelcinnamidederivatives AT qinzhaohai designsynthesisandantifungalinsecticidalevaluationofnovelcinnamidederivatives |