Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo

Levuglandins (LGs) and isolevuglandins (isoLGs), formed by rearrangement of endoperoxide intermediates generated through the cyclooxygenase and free radical induced oxidation of polyunsaturated fatty acids (PUFAs), are extraordinarily reactive, forming covalent adducts incorporating protein lysyl ε-...

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Detalles Bibliográficos
Autores principales: Zhang, Ming, Li, Wei, Li, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264246/
https://www.ncbi.nlm.nih.gov/pubmed/21705973
http://dx.doi.org/10.3390/molecules16075333
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author Zhang, Ming
Li, Wei
Li, Tao
author_facet Zhang, Ming
Li, Wei
Li, Tao
author_sort Zhang, Ming
collection PubMed
description Levuglandins (LGs) and isolevuglandins (isoLGs), formed by rearrangement of endoperoxide intermediates generated through the cyclooxygenase and free radical induced oxidation of polyunsaturated fatty acids (PUFAs), are extraordinarily reactive, forming covalent adducts incorporating protein lysyl ε-amino groups. Because they accumulate, these adducts provide a dosimeter of oxidative injury. This review provides an updated and comprehensive overview of the generation of LG/isoLG in vitro and in vivo and the detection methods for the adducts of LG/isoLG and biological molecules in vivo.
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spelling pubmed-62642462018-12-10 Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo Zhang, Ming Li, Wei Li, Tao Molecules Review Levuglandins (LGs) and isolevuglandins (isoLGs), formed by rearrangement of endoperoxide intermediates generated through the cyclooxygenase and free radical induced oxidation of polyunsaturated fatty acids (PUFAs), are extraordinarily reactive, forming covalent adducts incorporating protein lysyl ε-amino groups. Because they accumulate, these adducts provide a dosimeter of oxidative injury. This review provides an updated and comprehensive overview of the generation of LG/isoLG in vitro and in vivo and the detection methods for the adducts of LG/isoLG and biological molecules in vivo. MDPI 2011-06-24 /pmc/articles/PMC6264246/ /pubmed/21705973 http://dx.doi.org/10.3390/molecules16075333 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Zhang, Ming
Li, Wei
Li, Tao
Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo
title Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo
title_full Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo
title_fullStr Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo
title_full_unstemmed Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo
title_short Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo
title_sort generation and detection of levuglandins and isolevuglandins in vitro and in vivo
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264246/
https://www.ncbi.nlm.nih.gov/pubmed/21705973
http://dx.doi.org/10.3390/molecules16075333
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