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Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives

A hydrophilic amino-terminated poly(ethylene glycol)-type dual linker for solid phase synthesis of oleanolic acid derivatives using trityl chloride resin was designed and synthesized for the first time. Model reactions in both liquid and solid phase were performed to show the feasibility of its sele...

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Detalles Bibliográficos
Autores principales: Wang, Shaorong, Fang, Weishuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264254/
https://www.ncbi.nlm.nih.gov/pubmed/21654580
http://dx.doi.org/10.3390/molecules16064748
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author Wang, Shaorong
Fang, Weishuo
author_facet Wang, Shaorong
Fang, Weishuo
author_sort Wang, Shaorong
collection PubMed
description A hydrophilic amino-terminated poly(ethylene glycol)-type dual linker for solid phase synthesis of oleanolic acid derivatives using trityl chloride resin was designed and synthesized for the first time. Model reactions in both liquid and solid phase were performed to show the feasibility of its selective cleavage at two different sites. The biological assay results indicated that the long and flexible alkyl ether functionality in the linker is less likely to be critical for the binding event. Following the successful solid-phase synthesis of model compounds, the potential of this dual linker in reaction monitoring and target identification is deemed worthy of further study.
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spelling pubmed-62642542018-12-10 Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives Wang, Shaorong Fang, Weishuo Molecules Article A hydrophilic amino-terminated poly(ethylene glycol)-type dual linker for solid phase synthesis of oleanolic acid derivatives using trityl chloride resin was designed and synthesized for the first time. Model reactions in both liquid and solid phase were performed to show the feasibility of its selective cleavage at two different sites. The biological assay results indicated that the long and flexible alkyl ether functionality in the linker is less likely to be critical for the binding event. Following the successful solid-phase synthesis of model compounds, the potential of this dual linker in reaction monitoring and target identification is deemed worthy of further study. MDPI 2011-06-08 /pmc/articles/PMC6264254/ /pubmed/21654580 http://dx.doi.org/10.3390/molecules16064748 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wang, Shaorong
Fang, Weishuo
Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives
title Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives
title_full Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives
title_fullStr Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives
title_full_unstemmed Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives
title_short Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives
title_sort design and synthesis of a dual linker for solid phase synthesis of oleanolic acid derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264254/
https://www.ncbi.nlm.nih.gov/pubmed/21654580
http://dx.doi.org/10.3390/molecules16064748
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