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Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives
A hydrophilic amino-terminated poly(ethylene glycol)-type dual linker for solid phase synthesis of oleanolic acid derivatives using trityl chloride resin was designed and synthesized for the first time. Model reactions in both liquid and solid phase were performed to show the feasibility of its sele...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264254/ https://www.ncbi.nlm.nih.gov/pubmed/21654580 http://dx.doi.org/10.3390/molecules16064748 |
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author | Wang, Shaorong Fang, Weishuo |
author_facet | Wang, Shaorong Fang, Weishuo |
author_sort | Wang, Shaorong |
collection | PubMed |
description | A hydrophilic amino-terminated poly(ethylene glycol)-type dual linker for solid phase synthesis of oleanolic acid derivatives using trityl chloride resin was designed and synthesized for the first time. Model reactions in both liquid and solid phase were performed to show the feasibility of its selective cleavage at two different sites. The biological assay results indicated that the long and flexible alkyl ether functionality in the linker is less likely to be critical for the binding event. Following the successful solid-phase synthesis of model compounds, the potential of this dual linker in reaction monitoring and target identification is deemed worthy of further study. |
format | Online Article Text |
id | pubmed-6264254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62642542018-12-10 Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives Wang, Shaorong Fang, Weishuo Molecules Article A hydrophilic amino-terminated poly(ethylene glycol)-type dual linker for solid phase synthesis of oleanolic acid derivatives using trityl chloride resin was designed and synthesized for the first time. Model reactions in both liquid and solid phase were performed to show the feasibility of its selective cleavage at two different sites. The biological assay results indicated that the long and flexible alkyl ether functionality in the linker is less likely to be critical for the binding event. Following the successful solid-phase synthesis of model compounds, the potential of this dual linker in reaction monitoring and target identification is deemed worthy of further study. MDPI 2011-06-08 /pmc/articles/PMC6264254/ /pubmed/21654580 http://dx.doi.org/10.3390/molecules16064748 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Wang, Shaorong Fang, Weishuo Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives |
title | Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives |
title_full | Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives |
title_fullStr | Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives |
title_full_unstemmed | Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives |
title_short | Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives |
title_sort | design and synthesis of a dual linker for solid phase synthesis of oleanolic acid derivatives |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264254/ https://www.ncbi.nlm.nih.gov/pubmed/21654580 http://dx.doi.org/10.3390/molecules16064748 |
work_keys_str_mv | AT wangshaorong designandsynthesisofaduallinkerforsolidphasesynthesisofoleanolicacidderivatives AT fangweishuo designandsynthesisofaduallinkerforsolidphasesynthesisofoleanolicacidderivatives |