One-Pot Synthesis of Novel 2,3-Dihydro-1H-indazoles

A copper(I)-mediated one-pot synthesis of 2,3-dihydro-1H-indazole heterocycles has been developed. This synthetic route provides the desired indazoles in moderate to good yields (55%–72%) which are substantially better than those achievable with an alternative two-step reaction sequence. The reactio...

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Detalles Bibliográficos
Autores principales: Breton, Gary W., Lepore, Antonio J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264256/
https://www.ncbi.nlm.nih.gov/pubmed/22089862
http://dx.doi.org/10.3390/molecules16119553
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author Breton, Gary W.
Lepore, Antonio J.
author_facet Breton, Gary W.
Lepore, Antonio J.
author_sort Breton, Gary W.
collection PubMed
description A copper(I)-mediated one-pot synthesis of 2,3-dihydro-1H-indazole heterocycles has been developed. This synthetic route provides the desired indazoles in moderate to good yields (55%–72%) which are substantially better than those achievable with an alternative two-step reaction sequence. The reaction is tolerant of functionality on the aromatic ring.
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spelling pubmed-62642562018-12-10 One-Pot Synthesis of Novel 2,3-Dihydro-1H-indazoles Breton, Gary W. Lepore, Antonio J. Molecules Article A copper(I)-mediated one-pot synthesis of 2,3-dihydro-1H-indazole heterocycles has been developed. This synthetic route provides the desired indazoles in moderate to good yields (55%–72%) which are substantially better than those achievable with an alternative two-step reaction sequence. The reaction is tolerant of functionality on the aromatic ring. MDPI 2011-11-16 /pmc/articles/PMC6264256/ /pubmed/22089862 http://dx.doi.org/10.3390/molecules16119553 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Breton, Gary W.
Lepore, Antonio J.
One-Pot Synthesis of Novel 2,3-Dihydro-1H-indazoles
title One-Pot Synthesis of Novel 2,3-Dihydro-1H-indazoles
title_full One-Pot Synthesis of Novel 2,3-Dihydro-1H-indazoles
title_fullStr One-Pot Synthesis of Novel 2,3-Dihydro-1H-indazoles
title_full_unstemmed One-Pot Synthesis of Novel 2,3-Dihydro-1H-indazoles
title_short One-Pot Synthesis of Novel 2,3-Dihydro-1H-indazoles
title_sort one-pot synthesis of novel 2,3-dihydro-1h-indazoles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264256/
https://www.ncbi.nlm.nih.gov/pubmed/22089862
http://dx.doi.org/10.3390/molecules16119553
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