(+)- Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble

A new neolignan, 3,4-dimethoxy-3′,4′-methylenedioxy-2,9-epoxy-6,7-cyclo-1,8-neolign-11-en-5(5H)-one, which has been named (+)-kunstlerone (1), together with six known alkaloids: (+)-norboldine (2), (+)-N-methylisococlaurine (3), (+)-cassythicine (4), (+)-laurotetanine (5), (+)-boldine (6) and (-)-pa...

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Detalles Bibliográficos
Autores principales: Mollataghi, Abbas, Hadi, A Hamid A, Awang, Khalijah, Mohamad, Jamaludin, Litaudon, Marc, Mukhtar, Mat Ropi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264304/
https://www.ncbi.nlm.nih.gov/pubmed/21818061
http://dx.doi.org/10.3390/molecules16086582
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author Mollataghi, Abbas
Hadi, A Hamid A
Awang, Khalijah
Mohamad, Jamaludin
Litaudon, Marc
Mukhtar, Mat Ropi
author_facet Mollataghi, Abbas
Hadi, A Hamid A
Awang, Khalijah
Mohamad, Jamaludin
Litaudon, Marc
Mukhtar, Mat Ropi
author_sort Mollataghi, Abbas
collection PubMed
description A new neolignan, 3,4-dimethoxy-3′,4′-methylenedioxy-2,9-epoxy-6,7-cyclo-1,8-neolign-11-en-5(5H)-one, which has been named (+)-kunstlerone (1), together with six known alkaloids: (+)-norboldine (2), (+)-N-methylisococlaurine (3), (+)-cassythicine (4), (+)-laurotetanine (5), (+)-boldine (6) and (-)-pallidine (7), were isolated from the leaves of Beilschmiedia kunstleri. The structures were established through various spectroscopic methods notably 1D- and 2D-NMR, UV, IR and LCMS-IT-TOF. (+)- Kunstlerone (1) showed a strong antioxidant activity, with an SC(50) of 20.0 µg/mL.
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spelling pubmed-62643042018-12-10 (+)- Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble Mollataghi, Abbas Hadi, A Hamid A Awang, Khalijah Mohamad, Jamaludin Litaudon, Marc Mukhtar, Mat Ropi Molecules Article A new neolignan, 3,4-dimethoxy-3′,4′-methylenedioxy-2,9-epoxy-6,7-cyclo-1,8-neolign-11-en-5(5H)-one, which has been named (+)-kunstlerone (1), together with six known alkaloids: (+)-norboldine (2), (+)-N-methylisococlaurine (3), (+)-cassythicine (4), (+)-laurotetanine (5), (+)-boldine (6) and (-)-pallidine (7), were isolated from the leaves of Beilschmiedia kunstleri. The structures were established through various spectroscopic methods notably 1D- and 2D-NMR, UV, IR and LCMS-IT-TOF. (+)- Kunstlerone (1) showed a strong antioxidant activity, with an SC(50) of 20.0 µg/mL. MDPI 2011-08-04 /pmc/articles/PMC6264304/ /pubmed/21818061 http://dx.doi.org/10.3390/molecules16086582 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Mollataghi, Abbas
Hadi, A Hamid A
Awang, Khalijah
Mohamad, Jamaludin
Litaudon, Marc
Mukhtar, Mat Ropi
(+)- Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble
title (+)- Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble
title_full (+)- Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble
title_fullStr (+)- Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble
title_full_unstemmed (+)- Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble
title_short (+)- Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble
title_sort (+)- kunstlerone, a new antioxidant neolignan from the leaves of beilschmiedia kunstleri gamble
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264304/
https://www.ncbi.nlm.nih.gov/pubmed/21818061
http://dx.doi.org/10.3390/molecules16086582
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