Maleimido-Functionalized NOTA Derivatives as Bifunctional Chelators for Site-Specific Radiolabeling

Two basic and simple synthetic routes for mono- and bis-maleimide bearing 1,4,7-triazacyclononane-N,N’,N’’-triacetic acid (NOTA) chelators as new bifunctional chelators are described. The syntheses are characterized by their simplicity and short reaction times, as well as practical purification meth...

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Autores principales: Förster, Christian, Schubert, Maik, Pietzsch, Hans-Jürgen, Steinbach, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264318/
https://www.ncbi.nlm.nih.gov/pubmed/21697778
http://dx.doi.org/10.3390/molecules16065228
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author Förster, Christian
Schubert, Maik
Pietzsch, Hans-Jürgen
Steinbach, Jörg
author_facet Förster, Christian
Schubert, Maik
Pietzsch, Hans-Jürgen
Steinbach, Jörg
author_sort Förster, Christian
collection PubMed
description Two basic and simple synthetic routes for mono- and bis-maleimide bearing 1,4,7-triazacyclononane-N,N’,N’’-triacetic acid (NOTA) chelators as new bifunctional chelators are described. The syntheses are characterized by their simplicity and short reaction times, as well as practical purification methods and acceptable to very good chemical yields. The usefulness of these two synthetic pathways is demonstrated by the preparation of a set of mono- and bis-maleimide functionalized NOTA derivatives. In conclusion, these two methods can easily be expanded to the syntheses of further tailored maleimide-NOTA chelators for diverse applications.
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spelling pubmed-62643182018-12-10 Maleimido-Functionalized NOTA Derivatives as Bifunctional Chelators for Site-Specific Radiolabeling Förster, Christian Schubert, Maik Pietzsch, Hans-Jürgen Steinbach, Jörg Molecules Article Two basic and simple synthetic routes for mono- and bis-maleimide bearing 1,4,7-triazacyclononane-N,N’,N’’-triacetic acid (NOTA) chelators as new bifunctional chelators are described. The syntheses are characterized by their simplicity and short reaction times, as well as practical purification methods and acceptable to very good chemical yields. The usefulness of these two synthetic pathways is demonstrated by the preparation of a set of mono- and bis-maleimide functionalized NOTA derivatives. In conclusion, these two methods can easily be expanded to the syntheses of further tailored maleimide-NOTA chelators for diverse applications. MDPI 2011-06-22 /pmc/articles/PMC6264318/ /pubmed/21697778 http://dx.doi.org/10.3390/molecules16065228 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Förster, Christian
Schubert, Maik
Pietzsch, Hans-Jürgen
Steinbach, Jörg
Maleimido-Functionalized NOTA Derivatives as Bifunctional Chelators for Site-Specific Radiolabeling
title Maleimido-Functionalized NOTA Derivatives as Bifunctional Chelators for Site-Specific Radiolabeling
title_full Maleimido-Functionalized NOTA Derivatives as Bifunctional Chelators for Site-Specific Radiolabeling
title_fullStr Maleimido-Functionalized NOTA Derivatives as Bifunctional Chelators for Site-Specific Radiolabeling
title_full_unstemmed Maleimido-Functionalized NOTA Derivatives as Bifunctional Chelators for Site-Specific Radiolabeling
title_short Maleimido-Functionalized NOTA Derivatives as Bifunctional Chelators for Site-Specific Radiolabeling
title_sort maleimido-functionalized nota derivatives as bifunctional chelators for site-specific radiolabeling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264318/
https://www.ncbi.nlm.nih.gov/pubmed/21697778
http://dx.doi.org/10.3390/molecules16065228
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