Synthesis of No-Carrier-Added 4-[(18)F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide

4-[(18)F]Fluorophenol is a versatile synthon for the synthesis of more complex radiopharmaceuticals bearing a 4-[(18)F]fluorophenoxy moiety. In order to prepare 4-[(18)F]fluorophenol in no-carrier-added (n.c.a.) form only a nucleophilic labelling method starting from [(18)F]fluoride is suitable. In...

Descripción completa

Detalles Bibliográficos
Autores principales: Ross, Tobias L., Ermert, Johannes, Coenen, Heinz H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264319/
https://www.ncbi.nlm.nih.gov/pubmed/21900864
http://dx.doi.org/10.3390/molecules16097621
_version_ 1783375469012320256
author Ross, Tobias L.
Ermert, Johannes
Coenen, Heinz H.
author_facet Ross, Tobias L.
Ermert, Johannes
Coenen, Heinz H.
author_sort Ross, Tobias L.
collection PubMed
description 4-[(18)F]Fluorophenol is a versatile synthon for the synthesis of more complex radiopharmaceuticals bearing a 4-[(18)F]fluorophenoxy moiety. In order to prepare 4-[(18)F]fluorophenol in no-carrier-added (n.c.a.) form only a nucleophilic labelling method starting from [(18)F]fluoride is suitable. In this paper a new, two step radiosynthesis starting from 4-benzyloxyphenyl-(2-thienyl)iodonium bromide and [(18)F]fluoride with subsequent deprotection is described, yielding n.c.a. [(18)F]fluorophenol in 34 to 36% radiochemical yield.
format Online
Article
Text
id pubmed-6264319
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62643192018-12-10 Synthesis of No-Carrier-Added 4-[(18)F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide Ross, Tobias L. Ermert, Johannes Coenen, Heinz H. Molecules Communication 4-[(18)F]Fluorophenol is a versatile synthon for the synthesis of more complex radiopharmaceuticals bearing a 4-[(18)F]fluorophenoxy moiety. In order to prepare 4-[(18)F]fluorophenol in no-carrier-added (n.c.a.) form only a nucleophilic labelling method starting from [(18)F]fluoride is suitable. In this paper a new, two step radiosynthesis starting from 4-benzyloxyphenyl-(2-thienyl)iodonium bromide and [(18)F]fluoride with subsequent deprotection is described, yielding n.c.a. [(18)F]fluorophenol in 34 to 36% radiochemical yield. MDPI 2011-09-06 /pmc/articles/PMC6264319/ /pubmed/21900864 http://dx.doi.org/10.3390/molecules16097621 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Ross, Tobias L.
Ermert, Johannes
Coenen, Heinz H.
Synthesis of No-Carrier-Added 4-[(18)F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide
title Synthesis of No-Carrier-Added 4-[(18)F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide
title_full Synthesis of No-Carrier-Added 4-[(18)F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide
title_fullStr Synthesis of No-Carrier-Added 4-[(18)F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide
title_full_unstemmed Synthesis of No-Carrier-Added 4-[(18)F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide
title_short Synthesis of No-Carrier-Added 4-[(18)F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide
title_sort synthesis of no-carrier-added 4-[(18)f]fluorophenol from 4-benzyloxyphenyl-(2-thienyl)iodonium bromide
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264319/
https://www.ncbi.nlm.nih.gov/pubmed/21900864
http://dx.doi.org/10.3390/molecules16097621
work_keys_str_mv AT rosstobiasl synthesisofnocarrieradded418ffluorophenolfrom4benzyloxyphenyl2thienyliodoniumbromide
AT ermertjohannes synthesisofnocarrieradded418ffluorophenolfrom4benzyloxyphenyl2thienyliodoniumbromide
AT coenenheinzh synthesisofnocarrieradded418ffluorophenolfrom4benzyloxyphenyl2thienyliodoniumbromide

Ejemplares similares